Abstract
Background
Mitochondrial dynamics disorders contribute to the pathogenesis of many diseases involving type 2 diabetes. It appears that exercise training is a strategy for reversing the unbalance between fusion and fission, but, to our understanding, effects of aerobic exercise on this particular issue have not been studied in cardiac myocytes.
Aims
To demonstrate if 12 weeks of aerobic exercise has a significant impact on Dynamin Related Protein 1 (DRP1), Mitofusin2 (MFN2) and Optic Atrophy 1 (OPA1) expressions in cardiac muscle of type 2 diabetic rats.
Methods
10 Wistar rats with an average age of 10 weeks were divided randomly into two groups of five: diabetic control and diabetic exercise. The latter was submitted to a 12-week (5 days a week, 30 min/day) aerobic exercise. 48 h after the last session of exercise, cardiac samples were obtained for genetic experiments. T-test was used for data analysis at p ≤ 0.05.
Results
OPA1 expression was increased significantly (p = 0.03) while MFN2 and DRP1 expressions were elevated insignificantly (p = 0.165, p = 0.19).
Conclusion
This study shows that aerobic training is likely to regulate mitochondrial fission and fusion in cardiac muscle of type 2 diabetic rats. Although more research is necessary.
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Notes
Prolyl-hydroxylases.
Body weight.
Streptozotocin.
Enzyme-linked immunosorbent assay.
AMP-activated protein kinase.
Oxidative phosphorylation.
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Zafaranieh, S., Choobineh, S. & Soori, R. The effect of 12 weeks of aerobic exercise on mitochondrial dynamics in cardiac myocytes of type 2 diabetic rats. Sport Sci Health 14, 305–312 (2018). https://doi.org/10.1007/s11332-018-0430-9
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DOI: https://doi.org/10.1007/s11332-018-0430-9