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Weight gain may affect mandibular advancement device therapy in patients with obstructive sleep apnea: a retrospective study

  • Sleep Breathing Physiology and Disorders • Original Article
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Abstract

Purpose

The aim was to analyze whether or not weight gain influences the treatment outcome of patients with obstructive sleep apnea (OSA) treated with mandibular advancement devices (MAD).

Methods

As a part of a follow-up study among OSA patients treated with MAD in primary oral health care, a group of 28 patients reporting worsening of daytime or nighttime symptoms of OSA was given closer examination. Altogether, 21 subjects had a complete set of recordings and were enrolled into the study.

Results

Only three subjects had lost weight during the study period. The mean weight gain of 3.6 kg ± 7.1 kg was significant (p = 0.035). According to linear regression, weight gain was independently significantly associated with lower mean peripheral oxygen saturation 92.4 (SD 1.8 (% per hour) (p = 0.019)) and lowest oxygen saturation 80.1 (SD 7.2 (%) (p = 0.024)) scores.

Conclusions

Weight gain is detrimentally associated with MAD treatment in patients with OSA. These findings suggest that regular follow-up by an experienced dentist is advisable to assess for possible worsening of OSA. Patient support to encourage weight control may be an important adjunct to MAD treatment for OSA.

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Authors and Affiliations

  1. City of Helsinki, Department of Social Services and Health Care, POB 6420, 00099, Helsinki, Finland

    Tiina-Riitta Vuorjoki-Ranta

  2. Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands

    Ghizlane Aarab & Frank Lobbezoo

  3. Oivauni Sleep Clinic, Kuopio, Finland

    Henri Tuomilehto

  4. Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

    Henri Tuomilehto

  5. Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland

    Jari Ahlberg

  6. City of Helsinki, Department of Social Services and Health Care, Unit for Specialized Oral Care in the Metropolitan Area and Kirkkonummi, Helsinki, Finland

    Jari Ahlberg

  7. Institute of Dentistry, University of Eastern Finland, Kuopio, Finland

    Jari Ahlberg

Authors
  1. Tiina-Riitta Vuorjoki-Ranta
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  2. Ghizlane Aarab
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  3. Frank Lobbezoo
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  4. Henri Tuomilehto
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  5. Jari Ahlberg
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Corresponding author

Correspondence to Tiina-Riitta Vuorjoki-Ranta.

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The authors declare that they have no conflict of interest.

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For this type of study, formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Vuorjoki-Ranta, TR., Aarab, G., Lobbezoo, F. et al. Weight gain may affect mandibular advancement device therapy in patients with obstructive sleep apnea: a retrospective study. Sleep Breath 23, 531–534 (2019). https://doi.org/10.1007/s11325-018-1728-1

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  • DOI: https://doi.org/10.1007/s11325-018-1728-1

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