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High probability and frequency of EGFR mutations in non-small cell lung cancer with brain metastases

  • Clinical Study
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Abstract

Lung cancer is the leading cause of cancer death in men and women worldwide. Brain metastasis (BMs) of non-small cell lung cancer (NSCLC) is the most important cause of death. This study aimed to explore the association of epidermal growth factor receptor (EGFR) mutations and BMs in NSCLC. We analyzed 50 NSCLC patients with BMs and 50 match-paired NSCLC patients with no brain metastases (NBMs). The EGFR mutation status of primary lesions was detected using the amplification refractory mutation system polymerase chain reaction. The BMs patients had a higher frequency of EGFR mutations than the NBMs patients (52.0 vs. 22.0% respectively, P < 0.001), in both adenocarcinoma (60.5 vs. 30.6%, P = 0.003) and squamous carcinoma (37.5 vs. 0%, P = 0.04). The incidence of BMs in patients with EGFR mutations was higher than in patients with wild-type EGFR (70.3 vs. 38.1%, P = 002). NSCLC patients with BMs had a higher incidence of EGFR mutations and those with mutant EGFR had a higher frequency of BMs. EGFR mutations may promote brain metastasis growth of NSCLC.

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Acknowledgements

This work was granted partly by Natural Science Foundation of Shanghai, China (No. 16ZR1404300), Municipal Commission of Health and Family Planning of Shanghai, China (No. 201440584) and Science and Technology Development Foundation of Baoshan, Shanghai, China (No. 14-E-27).

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Authors and Affiliations

  1. Department of Oncology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China

    Mengxi Ge, Xinli Zhou, Ruofan Huang, Xiaohua Liang & Qiong Zhan

  2. Company 4, Battalion 1, Cadet Brigade 1, Fourth Military Medical University, Xi’an, 710032, China

    Yingjie Zhuang

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  1. Mengxi Ge
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  2. Yingjie Zhuang
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  3. Xinli Zhou
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  5. Xiaohua Liang
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Correspondence to Xiaohua Liang.

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I declare any financial or other interests that have related to the work described in the paper when it is first submitted.

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Ge, M., Zhuang, Y., Zhou, X. et al. High probability and frequency of EGFR mutations in non-small cell lung cancer with brain metastases. J Neurooncol 135, 413–418 (2017). https://doi.org/10.1007/s11060-017-2590-x

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