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Implicating chromosomal aberrations with meningioma growth and recurrence: results from FISH and MIB-I analysis of grades I and II meningioma tissue

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Abstract

The fluorescence in situ hybridization (FISH) technique was used in 111 WHO grades I and II meningioma patients. Clinical, radiological, pathological, and immunohistochemical data were compared to aberrations of chromosomes 1p, 14q, and 22q determined by FISH. Significant differences for MIB-1 labeling were found between grades I and II tumors (p < 0.001), and between grade I tumors that recurred and those that did not recur (p < 0.001). Chromosomal aberrations were detected with FISH analysis in nearly 50% of grade I, and in 93% of grade II meningiomas. The numbers of chromosomal aberrations correlated significantly to MIB-1 (p < 0.001), with signs of grossly invasive tumor growth (p < 0.001), and with tumor recurrence (p < 0.01). The findings suggest that adding FISH analysis may allow better prediction of possible meningioma recurrence and may be a useful adjunct for therapy decisions.

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Acknowledgments

The authors thank Nicole C. Hank and Kathy Goehring for expert technical assistance with the FISH and MIB-1 preparation. This work was supported by a generous donation from the Newsome Endowed Chair of Neurosurgery Research at the Barrow Neurological Institute.

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Authors and Affiliations

  1. Neurosurgery Research, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 85013, USA

    Wolfgang K. Pfisterer, William P. Hendricks, Adrienne C. Scheck & Mark C. Preul

  2. Neuro-Oncology Research, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 85013, USA

    Wolfgang K. Pfisterer & Adrienne C. Scheck

  3. Division of Neuropathology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 85013, USA

    Stephen W. Coons

  4. Department of Neurosurgery, Sozialmedizinisches Zentrum-Ost, Donauspital, Langobardenstr. 122, 1190, Vienna, Austria

    Wolfgang K. Pfisterer & Fahmy Aboul-Enein

Authors
  1. Wolfgang K. Pfisterer
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  2. Stephen W. Coons
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  3. Fahmy Aboul-Enein
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  4. William P. Hendricks
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  5. Adrienne C. Scheck
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  6. Mark C. Preul
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Correspondence to Wolfgang K. Pfisterer.

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Pfisterer, W.K., Coons, S.W., Aboul-Enein, F. et al. Implicating chromosomal aberrations with meningioma growth and recurrence: results from FISH and MIB-I analysis of grades I and II meningioma tissue. J Neurooncol 87, 43–50 (2008). https://doi.org/10.1007/s11060-007-9498-9

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  • DOI: https://doi.org/10.1007/s11060-007-9498-9

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