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Electrografting of a biodegradable layer as a primer adhesion coating onto a metallic stent: in vitro and in vivo evaluations

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Abstract

Drug-eluting stents have been developed to reduce the risk of restenosis after angioplasty. To facilitate the adhesion of a poly(lactic acid) (PLA) overlayer loaded with rapamycin (20 wt%), a biodegradable macromonomer based on poly(lactic acid) (HEMA-PLA) was grafted onto the metallic stent by electrografting in a one-step reaction involving the immobilization of aryl diazonium onto the metal followed by an in situ surface electro-polymerization. The HEMA-PLA coating was chemically characterized. Mechanical performance during stent expansion was tested. Morphology examinations showed a strong adhesion of PLA topcoat in the presence of the electrografted layer. Biocompatibility and degradation of the coating were studied in vitro and in vivo in rabbit iliac arteries. These 28 days implantations resulted in a minimal inflammatory process with a partial degradation of the coating. These results suggest that this kind of anchoring of a biodegradable layer shows great potential for drug-eluting stents.

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Acknowledgments

The authors wish to thank the French National Agency for Research (TechSan Program) for its financial support.

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Authors and Affiliations

  1. Equipe Systèmes Polymères Complexes, Institut de Chimie et des Matériaux Paris-Est-UMR 7182, CNRS, Université Paris-Est Créteil Val-de-Marne, 2 rue Henri Dunant, 94320, Thiais, France

    Gwenaelle Vergnol, Estelle Renard & Valerie Langlois

  2. INSERM U915, Institut du thorax, 8 quai Moncousu, 44007, Nantes, France

    Patrice Guerin & Gervaise Loirand

  3. Alchimedics S.A., 15, rue du buisson aux fraises. ZI de la bonde, 91300, Massy, France

    Ferial Haroun, Aymeric Seron & Christophe Bureau

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  1. Gwenaelle Vergnol
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  2. Estelle Renard
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  3. Ferial Haroun
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  4. Patrice Guerin
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Correspondence to Gwenaelle Vergnol.

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Vergnol, G., Renard, E., Haroun, F. et al. Electrografting of a biodegradable layer as a primer adhesion coating onto a metallic stent: in vitro and in vivo evaluations. J Mater Sci: Mater Med 24, 2729–2739 (2013). https://doi.org/10.1007/s10856-013-5015-1

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