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Minimally invasive combined glaucoma and cataract surgery: clinical results of the smallest ab interno gel stent

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Abstract

Purpose

To verify the efficacy in intraocular pressure (IOP) reduction and safety of the smallest gel stent (XEN 45 Gel Stent) microincisional glaucoma surgery combined with microincisional cataract surgery (MICS).

Methods

Nonrandomized prospective clinical study. Forty-one eyes of 33 patients with open-angle glaucoma underwent a XEN 45 Gel Stent implantation combined with MICS. Treatment outcomes analyzed included: IOP, medication use, intra- and postoperative complications. At the end of the follow-up, we evaluated the complete success, defined as a postoperative IOP ≥ 6 and ≤17 mmHg without glaucoma medications and the qualified success defined as a postoperative IOP ≥ 6 and ≤17 mmHg, with glaucoma medications.

Results

The mean preoperative IOP was 22.5 ± 3.7 mmHg on 2.5 ± 0.9 medication classes. After 12 months, the mean postoperative IOP was 13.1 ± 2.4 mmHg (mean IOP reduction of 41.82%) with a mean of 0.4 ± 0.8 medication classes (P < 0.05 for IOP and medications). The complete success rate was achieved in 80.4% and a qualified success in 97.5%. There were no major intra- and postoperative complications during the first year of follow-up.

Conclusions

This study demonstrated that the smaller diameter XEN 45 gel implant is statistically effective in reducing IOP and medications in glaucoma patients with a low rate of complications.

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Authors and Affiliations

  1. Ophthalmic Unit, San Bassiano Hospital, Via dei Lotti 40, 36061, Bassano del Grappa, Vicenza, Italy

    Alessandra De Gregorio, Luisa Russo & Simonetta Morselli

  2. Eye Clinic, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy

    Emilio Pedrotti

Authors
  1. Alessandra De Gregorio
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  2. Emilio Pedrotti
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  3. Luisa Russo
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  4. Simonetta Morselli
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Corresponding author

Correspondence to Alessandra De Gregorio.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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De Gregorio, A., Pedrotti, E., Russo, L. et al. Minimally invasive combined glaucoma and cataract surgery: clinical results of the smallest ab interno gel stent. Int Ophthalmol 38, 1129–1134 (2018). https://doi.org/10.1007/s10792-017-0571-x

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  • DOI: https://doi.org/10.1007/s10792-017-0571-x

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