Abstract
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases involve multiple pulmonary components, including airways and lungs that lead to their abnormal physiological functioning. Several signaling pathways have been reported to play an important role in the pathophysiology of respiratory diseases. These pathways, in addition, become the compounding factors contributing to the clinical outcomes in respiratory diseases. A range of signaling components such as Notch, Hedgehog, Wingless/Wnt, bone morphogenetic proteins, epidermal growth factor and fibroblast growth factor is primarily employed by these pathways in the eventual cascade of events. The different aberrations in such cell-signaling processes trigger the onset of respiratory diseases making the conventional therapeutic modalities ineffective. These challenges have prompted us to explore novel and effective approaches for the prevention and/or treatment of respiratory diseases. In this review, we have attempted to deliberate on the current literature describing the role of major cell signaling pathways in the pathogenesis of pulmonary diseases and discuss promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing pulmonary vascular pathology in such patients.
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Acknowledgements
Kamal Dua is supported by a project grant from Rebecca L. Cooper Medical Research Foundation and Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) for the TRIPLE I CAG Secondment/ Exchange grant. Philip M. Hansbro is supported by a fellowship from the National Health and Medical Research Council of Australia (NHMRC #1079187). Keshav Raj Paudel is supported by a fellowship from Prevent Cancer Foundation (PCF)/International Association for the Study of Lung Cancer (IASLC). Meenu is supported by the Graduate School of Health and University of Technology Sydney (International Research Training Program Scholarship (IRTP) and International Research Training Program Scholarship (IRTP))
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Mehta, M., Dhanjal, D.S., Paudel, K.R. et al. Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update. Inflammopharmacol 28, 795–817 (2020). https://doi.org/10.1007/s10787-020-00698-3
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DOI: https://doi.org/10.1007/s10787-020-00698-3