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Anti-inflammatory Effects of Vitamin E on Adjuvant-Induced Arthritis in Rats

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Abstract

Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund’s adjuvant (CFA). We observed an increase in arthritis scores, interleukin-1β and H2O2 levels, neutrophil and macrophage infiltration, thermal hyperalgesia, mechanical allodynia, and loss of function induced by intraplantar CFA injection. These effects were unaltered after 1 day, partially reversed after 3 days, and inhibited after 9 days after vit-E treatment. Furthermore, the concentration of vit-E was reduced and that of tumor necrosis factor-alpha was increased in the CFA-injected paw. Both effects were reversed from 1 to 9 days after vit-E treatment. However, vit-E treatment did not alter CFA-induced edema at any time. Thus, vit-E treatment produced an anti-inflammatory effect of slow onset in CFA, which demonstrates a disease-modifying drug profile.

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Acknowledgments

This study was supported by the Conselho Nacional de Desenvolvimento Científico (CNPq) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Brazil). We also acknowledge fellowships from CNPq.

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Authors and Affiliations

  1. Graduate Program in Biological Science: Toxicological Biochemistry, Department of Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima 1000, Camobi, CEP 97105-900, Santa Maria, RS, Brazil

    Mateus Fortes Rossato, Raquel Tonello, Ana Paula de Oliveira Ferreira & Juliano Ferreira

  2. Graduate Program in Pharmacology, Department of Pharmacology, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil

    Carin Hoffmeister & Juliano Ferreira

  3. Department of Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil

    Juliano Ferreira

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  1. Mateus Fortes Rossato
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  2. Carin Hoffmeister
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Correspondence to Mateus Fortes Rossato.

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Rossato, M.F., Hoffmeister, C., Tonello, R. et al. Anti-inflammatory Effects of Vitamin E on Adjuvant-Induced Arthritis in Rats. Inflammation 38, 606–615 (2015). https://doi.org/10.1007/s10753-014-9967-1

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