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Prevalence of Psychiatric Comorbidity in Symptomatic Gastroesophageal Reflux Subgroups

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Abstract

Background

Limited data exist regarding the psychosocial aspects of gastroesophageal reflux disease (GERD). Some GERD subgroups, such as functional heartburn and hypersensitive esophagus, might show different psychiatric comorbidities than others.

Aim

We aimed to evaluate the psychiatric comorbidities of GERD subgroups using a cross-sectional design.

Methods

A group of GERD patients at a tertiary outpatient clinic were evaluated via upper GIS (gastrointestinal system) endoscopy, esophageal manometry, and 24-h impedance–pH monitoring. Thirty-nine patients diagnosed with erosive reflux disease, 44 with non-erosive reflux disease, 20 with functional heartburn, 11 with hypersensitive esophagus, and 44 healthy controls participated. Psychiatric diagnoses were made using the Structured Clinical Interview for Diagnostics and Statistical Manual of Mental Disorders IV. Psychometric measurements of the patients were performed using the Somatosensory Amplification Scale, Beck Depression Inventory, State-Trait Anxiety Inventory, and Short-Form 36. Healthy controls were evaluated with the same psychometric scales except for the Short-Form 36.

Results

All of the GERD subgroups were significantly more depressed than the control group. Depressive disorders were significantly more prevalent in the functional heartburn group than in the non-erosive reflux disease and erosive reflux disease groups. The trait anxiety level of the functional heartburn group was significantly higher than those of the control and non-erosive reflux disease groups. The quality of life scores of the GERD subgroups were significantly lower than the population standards.

Conclusions

Depressive disorders were frequently comorbid in the GERD subgroups studied (30–65 %). It is essential to consider the high prevalence rates of comorbid depression when managing GERD.

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Authors and Affiliations

  1. Izmir Bozyaka Educational and Research Hospital, Izmir, Turkey

    Mustafa Melih Bilgi

  2. Department of Psychiatry, School of Medicine, Ege University, Bornova, Izmir, Turkey

    Baybars Veznedaroğlu

  3. Division of Gastroenterology, School of Medicine, Ege University, Bornova, Izmir, Turkey

    Rukiye Vardar, Esra Yıldırım & Serhat Bor

  4. Ege Reflux Group, Izmir, Turkey

    Mustafa Melih Bilgi, Rukiye Vardar, Esra Yıldırım & Serhat Bor

  5. Karabaglar State Clinics, 4025 Sok., Yunus Emre Mah., Karabaglar, Izmir, Turkey

    Mustafa Melih Bilgi

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  1. Mustafa Melih Bilgi
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Correspondence to Mustafa Melih Bilgi.

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Bilgi, M.M., Vardar, R., Yıldırım, E. et al. Prevalence of Psychiatric Comorbidity in Symptomatic Gastroesophageal Reflux Subgroups. Dig Dis Sci 62, 984–993 (2017). https://doi.org/10.1007/s10620-016-4273-4

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  • DOI: https://doi.org/10.1007/s10620-016-4273-4

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