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EUS-Guided Celiac Plexus Neurolysis for Pain due to Chronic Pancreatitis or Pancreatic Cancer Pain: A Meta-Analysis and Systematic Review

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Abstract

The objective of this study was to evaluate the efficacy of EUS-guided CPN for pain relief in patients with chronic pancreatitis and pancreatic cancer. An initial search identified 1,439 reference articles, of which 130 relevant articles were selected and reviewed. Data was extracted from 8 studies (N = 283) for EUS-guided CPN for pain due to pancreatic cancer and nine studies for chronic pancreatitis (N = 376) which met the inclusion criteria. With EUS-guided CPN, the pooled proportion of patients with pancreatic cancer that showed pain relief was 80.12% (95% CI = 74.47–85.22). In patients with pain due to chronic pancreatitis, EUS-guided CPN provided pain relief in 59.45% (95% CI = 54.51–64.30). In conclusion, EUS-guided CPN offers a safe alternative technique for pain relief in patients with chronic pancreatitis or pancreatic cancer. In patients with pain due to chronic pancreatitis, better techniques or injected materials are needed to improve the response.

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Abbreviations

CP:

Chronic pancreatitis

CPN:

Celiac plexus neurolysis

EUS:

Endoscopic ultrasound

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, CE443 Clinical Support & Education, University of Missouri-Columbia, Five Hospital Drive, DC043.00, Columbia, MO, 65212, USA

    Srinivas R. Puli, Jyotsna B. K. Reddy, Matthew L. Bechtold & Mainor R. Antillon

  2. GI Unit, Massachusetts General Hospital, Boston, MA, USA

    William R. Brugge

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  1. Srinivas R. Puli
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  2. Jyotsna B. K. Reddy
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Puli, S.R., Reddy, J.B.K., Bechtold, M.L. et al. EUS-Guided Celiac Plexus Neurolysis for Pain due to Chronic Pancreatitis or Pancreatic Cancer Pain: A Meta-Analysis and Systematic Review. Dig Dis Sci 54, 2330–2337 (2009). https://doi.org/10.1007/s10620-008-0651-x

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