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Endoscopic Resection of a Duodenal Gangliocytic Paraganglioma

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Abstract

A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of epithelioid cells, spindle cells, and ganglion-like cells. An endoscopic ultrasonography showed a round, well-demarcated, inhomogeneous, submucosal tumor in the 3rd-4th layer. We resected it by endoscopic mucosal resection.

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References

  1. Perrone T, Sibley RK, Rosai J (1985) Duodenal gangliocytic paraganglioma. An immunohistochemical and ultrastructural study and a hypothesis concerning its origin. Am J Pathol 9:31–41

    Article  CAS  Google Scholar 

  2. Scheithauer BW, Nora FE, Lechago J, Wick MP, Crawford BG, Weiland LH, Carney JA (1986) Duodenal gangliocytic paraganglioma. Clinicopathologicand immunohistorogical study of 11cases. Am J Clin Pathol 86:559–565

    PubMed  CAS  Google Scholar 

  3. Stephens M, Williams GT, Jasani B, Williams ED (1987) Synchronous duodenal neuroendocrine tumors in von Recklinghausen's disease—a case report of co-existing gangliocytic paraganglioma and somatostatin-rich glandular cartinoid. Histology 11:1331–1340

    CAS  Google Scholar 

  4. Dahl EV, Waugh JM, Dajin DC (1957) Gastrointestinal ganglioneuroma. Brief review with report of a duodenal ganglioneuroma. Am J Pathol 33:953–965

    PubMed  CAS  Google Scholar 

  5. Nakamura T, Ozawa T, Takehira Y, Kitagawa M, Yamada M, Yasumi K, Tamakoshi K, Kobayashi Y, Nakamura H (2002) Endoscopic resection of gangliocytic paraganglioma of the minor duodenal papilla: case report and review. Gastrointest Endosc 55:270–273

    Article  PubMed  Google Scholar 

  6. Burke A, Helwig E (1988) Gangliocytic paraganglioma of the small intestine. Lab Invest 58:13A (abstr)

    Google Scholar 

  7. Reed R, Daroca P, Harkin J (1977) Gangliocytic paraganglioma. Am J Surg Pathol 1:207–216

    Article  PubMed  CAS  Google Scholar 

  8. Scheithauer BW, Nora FE, LeChago J, Wick MR, Crawford BG, Weiland LH, Carney JA (1986) Duodenal gangliocytic paraganglioma:clinicopathologic and immunohistochemical study of 11 cases. Am J Clin Pathol 86:559–565

    PubMed  CAS  Google Scholar 

  9. Smithline AE, Hawes RH, Kopecky KK, Cummings OW, Kumar S (1993) Gangliocytic paraganglioma, a rare cause of upper gastrointestinal bleeding, endoscopic ultrasound findings presented. Dig Dis Sci 38:173–177

    Article  PubMed  CAS  Google Scholar 

  10. Coony T, Sweeney EC (1979) Paraganglioneuroma of duodenum: An evolutionary hybrid? J ClinPathol 31:233–244

    Google Scholar 

  11. Qizilbash AH (1973) Benign paraganglioma of duodenum. Arch Pathol 96:276–280

    PubMed  CAS  Google Scholar 

  12. Taylor HB, Helwig EB (1962) Benign nonchromaffin paragangliomas of duodenum. Virchows Arch [Pathol Anat] 335:356–366

    Article  CAS  Google Scholar 

  13. Kepes JJ, Zacharias DL (1971) Gangliocytic paraganglioma of the duodenum. A report of two cases with light and electron microscopic examination. Cancer 1:207–216

    Google Scholar 

  14. Schroder HD, Johannsen L (1986) Demonstration of S-100 protein in sustentacular cells of phaeochromocytomas and paragangliomas. Histopathology 10:1023–1033

    Article  PubMed  CAS  Google Scholar 

  15. Furihata M, Ohtsuki Y (1991) Immunohistochemical characterization of HLA-DR-antigen positive dendric cells in phaeochromocytomas and paragangliomas as a prognostic marker. Virchows Arch Pathol Anat Histopathol 418:33–39

    Article  CAS  Google Scholar 

  16. Barbareschi M, Frigo B, Aldovini D, Leonardi E, Cristina S, Falleni M (1989) Duodenal gangliocystic paraganglioma:r eport of a case and review of the literature. Virchows Arch A Pathol Avat Histopathol 416:81–89

    Article  CAS  Google Scholar 

  17. Bruke AP, Helwig EB (1989) Gangliocytic paraganglioma. Am J Clin Pathol 92:1–9

    Google Scholar 

  18. Imai K, Kobuke T, Yonehara S, Tokuoka S (1989) Duodenal gangliocytic paraganglioma with lymph node metastasis in a 17-year-old boy. Cancer 63:2540–2545

    Article  Google Scholar 

  19. Büchler M, Malfertheiner P, Baczako K, Krantzberger W, Berger HG (1985) A metastatic endocrine-neurogenic tumor of ampulla of Vater with multiple endocrine immunoreaction-malignant paraganglioma? Digestion 31:54–59

    Article  PubMed  Google Scholar 

  20. Dookhan DB, Miettinen M, Finkel G, Jibas Z (1993) Recurrent duodenal gangliocytic paraganglioma with lymph node metastases. Histopathology 22:399–401

    Article  PubMed  CAS  Google Scholar 

  21. Hashimoto S, Kawasaki S, Matsuzawa K, Harada H, Makuuchi M (1992) Gangliocytic paraganglioma of the papilla of Vater with regional lymph node metastasis. Am J Gastroenterol 87:1216–1218

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Kochi Medical School, Kohasu, Okoh-cho, Nankoku, Kochi, 783-8505,, Japan

    Tomoko Morita, Tomoko Onishi, Yoshinori Kuratani, Hiroshi Mizuta & Saburo Onishi

  2. Department of Endoscopy, Kochi Medical School, Nankoku, Kochi, Japan

    Satoru Tamura & Yuichi Yokoyama

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  1. Tomoko Morita
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  2. Satoru Tamura
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  3. Yuichi Yokoyama
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  4. Tomoko Onishi
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  5. Yoshinori Kuratani
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  6. Hiroshi Mizuta
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  7. Saburo Onishi
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Correspondence to Tomoko Morita.

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Morita, T., Tamura, S., Yokoyama, Y. et al. Endoscopic Resection of a Duodenal Gangliocytic Paraganglioma. Dig Dis Sci 52, 1400–1404 (2007). https://doi.org/10.1007/s10620-006-9370-3

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  • DOI: https://doi.org/10.1007/s10620-006-9370-3

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