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Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases

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Abstract

BRMS1 was discovered over a decade ago as a potential tumor suppressor gene. In this review, we summarize the recent findings about the structure of BRMS1, mechanisms of its action and a role of BRMS1 in the cancer progression. As a suppressor of metastasis, BRMS1 has demonstrated a variety of ways to act on the cell functions, such as cell migration, invasiveness, angiogenesis, cell survival, cytoskeleton rearrangements, cell adhesion, and immune recognition. This variety of effects is a likely reason behind the robustness of anti-metastatic influence of BRMS1. Intracellular signaling mechanisms employed by BRMS1 include regulation of transcription, EGF/HER2 signaling, and expression of NF-kB, fascin, osteopontin, and IL-6. Recently reported clinical studies confirm that BRMS1 can indeed be used as a prognostic marker. Approaches to employ BRMS1 in a development of anti-cancer treatment have also been made. The studies reviewed here with respect to BRMS1 structure, cellular effects, intracellular signaling, and clinical value consolidate the importance of BRMS1 in the development of metastasis.

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Abbreviations

aa:

Amino acids

NES:

Nuclear export signal

NLS:

Nuclear localization signal

NMR:

Nuclear-magnetic resonance

EMT:

Epithelial-to-mesenchymal transition

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Acknowledgments

This work was supported in part by “Oves Minnesfond” and Radiumhemmets Research Funds (#121202) to S.S.

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Authors and Affiliations

  1. Neurocentrum, Karolinska University Hospital, R2:04, Solna, SE-17176, Stockholm, Sweden

    Magdalena Anna Kodura & Serhiy Souchelnytskyi

  2. Department of Biotechnology, Kungliga Tekniska Högskolan, Stockholm, Sweden

    Magdalena Anna Kodura

  3. Oranta CancerDiagnostics AB (LLC), Uppsala, Sweden

    Serhiy Souchelnytskyi

  4. College of Medicine, Qatar University, Doha, Qatar

    Serhiy Souchelnytskyi

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  1. Magdalena Anna Kodura
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Correspondence to Magdalena Anna Kodura.

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Kodura, M.A., Souchelnytskyi, S. Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases. Cancer Metastasis Rev 34, 611–618 (2015). https://doi.org/10.1007/s10555-015-9583-z

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