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The Polymorphism of DNA Repair Gene ERCC2/XPD Arg156Arg and Susceptibility to Breast Cancer in a Chinese Population

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Abstract

Polymorphisms in DNA repair genes are good candidates for modifying cancer risk. ERCC2/XPD, a gene involved in nucleotide excision repair and basal transcription, may influence individual DNA repair capacity, particularly of bulky adducts. This is implicated in cancer susceptibility. To detect the association between ERCC2/XPD Arg156Arg and susceptibility to breast cancer in a Chinese population, we conducted a hospital-based case–control study consisting of 129 patients with breast cancer and 205 controls matched by age, gender, and ethnicity. PCR-RFLP was used for genotyping. No associations were found between ERCC2/XPD Arg156Arg and risk of breast cancer (AA/AC versus CC: OR = 0.79, 95% CI = 0.49–1.28, P = 0.33; AA versus CC: OR = 0.89, 95% CI = 0.49–1.63, P = 0.72; AC versus CC: OR = 0.74, 95% CI = 0.44–1.24, P = 0.25). Breast cancer cases with the variant AA genotype were marginally younger (mean age 45 years) than cases with the wild CC genotype (mean age 50 years) (P = 0.05). There were no differences in risk estimates in relation to menopause and occurrence of breast cancer. Our findings do not suggest that ERCC2/XPD Arg156Arg contributes to breast cancer susceptibility in a Chinese population.

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Acknowledgments

This study was approved by the Chinese Administration Office of Human Genetic Resources, No. (2001) 015, and was supported by Grant No. 30571016 from the National Natural Science Foundation of China; Grant No. 1081233-1-00-04 from the Foundation of Key Application Basis Studies, Science and Technology Bureau of Shenyang, P.R. China; Grant No. 2008S222 from the Key Laboratory Foundation of Science and Technology Research, Education Ministry of Liaoning Province, P.R. China; and Grant No. 20063018 from the Excellent Scholar Foundation of Shenyang Medical College, P.R. China. We thank our volunteers for donating their blood and collaborators for collection of blood samples and information.

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Authors and Affiliations

  1. Key Laboratory of Environment and Population Health of University in Liaoning Province, Shenyang Medical College, Shenyang, 110034, Liaoning, China

    Jiaoyang Yin, Duohong Liang, Rong Qi & Tiehua Song

  2. Department of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, 2860, Søborg, Denmark

    Ulla Vogel

  3. Department of Immunology, School of Basic Medical Sciences, Jilin University, Changchun, 130021, Jilin, China

    Yaping Chang

  4. Second Department of General Surgery, Liaoning People’s Hospital, Shenyang, 110042, Liaoning, China

    Zhengrong Liu

  5. Department of Oncology, Affiliated First Hospital of Liaoning Medical College, Jinzhou, 121001, Liaoning, China

    Li Yue

  6. Center of Reproductive Medicine, Key First Department of Shenyang City, Jinghua Hospital, Eastern Medical Group of Shenyang, Shenyang, 110005, Liaoning, China

    Xiaoling Sun

  7. Department of Cell Biology and Genetics, Shenyang Medical College, Shenyang, 110034, Liaoning, China

    Jiaoyang Yin, Duohong Liang, Rong Qi & Tiehua Song

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  1. Jiaoyang Yin
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  2. Duohong Liang
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  3. Ulla Vogel
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  4. Yaping Chang
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  8. Rong Qi
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  9. Tiehua Song
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Correspondence to Jiaoyang Yin.

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Yin, J., Liang, D., Vogel, U. et al. The Polymorphism of DNA Repair Gene ERCC2/XPD Arg156Arg and Susceptibility to Breast Cancer in a Chinese Population. Biochem Genet 47, 582–590 (2009). https://doi.org/10.1007/s10528-009-9246-2

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  • DOI: https://doi.org/10.1007/s10528-009-9246-2

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