Skip to main content

Advertisement

SpringerLink
Log in

Validation of international criteria for the diagnosis of ocular sarcoidosis proposed by the first international workshop on ocular sarcoidosis

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To validate the international criteria for the diagnosis of ocular sarcoidosis as proposed by the First International Workshop on Ocular Sarcoidosis (FIWOS).

Methods

A retrospective case-control study examined 370 consecutive uveitis patients at Tokyo Medical and Dental University Hospital. The study group consisted of 50 patients with biopsy-proven sarcoidosis and 320 control patients with other uveitis entities. Predictive values [sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)] were calculated for seven clinical signs, five laboratory tests, and the diagnostic criteria.

Results

With the exception of the liver enzyme tests, there was a significantly higher incidence of positive results for all clinical signs and laboratory tests in the biopsy-proven sarcoidosis patients than in the control uveitis patients. Although variability was noted in the predictive values of the seven clinical signs and five laboratory tests, the sensitivity, specificity, PPV, and NPV of the FIWOS criteria, which were based on the combined results of the clinical signs and laboratory tests, were 1.000, 0.956, 0.781, and 1.000, respectively.

Conclusions

The FIWOS criteria have high predictive values for diagnosing ocular sarcoidosis. To further confirm these findings, an international prospective multicenter study should be undertaken in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Statement on sarcoidosis. Joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med 1999;160:736–755.

    Google Scholar 

  2. Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med 1997;336:1224–1234.

    Article  CAS  PubMed  Google Scholar 

  3. Crick RP, Hoyle C, Smellie H. The eyes in sarcoidosis. Br J Ophthalmol 1961;45:461–481.

    Article  CAS  PubMed  Google Scholar 

  4. Jabs DA, Johns CJ. Ocular involvement in chronic sarcoidosis. Am J Ophthalmol 1986;102:297–301.

    CAS  PubMed  Google Scholar 

  5. Obenauf CD, Shaw HE, Sydnor CF, Klintworth GK. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol 1978;86:648–655.

    CAS  PubMed  Google Scholar 

  6. Yamamoto M. The concept, definition and diagnostic criteria of sarcoidosis [in Japanese with English abstract]. Nippon Rinsho 1994;52:1426–1432.

    CAS  PubMed  Google Scholar 

  7. Asukata Y, Ishihara M, Hasumi Y, et al. Guidelines for the diagnosis of ocular sarcoidosis. Ocul Immunol Inflamm 2008;16:77–81.

    Article  PubMed  Google Scholar 

  8. Kawaguchi T, Hanada A, Horie S, Sugamoto Y, Sugita S, Mochizuki M. Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients. Jpn J Ophthalmol 2007;51:121–126.

    Article  PubMed  Google Scholar 

  9. Herbort CP, Rao NA, Mochizuki M. International criteria for the diagnosis of ocular sarcoidosis: results of the first International Workshop on Ocular Sarcoidosis (IWOS). Ocul Immunol Inflamm 2009;17:160–169.

    Article  CAS  PubMed  Google Scholar 

  10. Mizushima Y. Revised diagnostic criteria for Behcet’s disease in 1987 [in Japanese]. Ryumachi 1988;28:66–70.

    CAS  PubMed  Google Scholar 

  11. Read RW, Holland GN, Rao NA, et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001;131:647–652.

    Article  CAS  PubMed  Google Scholar 

  12. Sugita S, Shimizu N, Watanabe K, et al. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthalmol 2008;92:928–932.

    Article  CAS  PubMed  Google Scholar 

  13. Sugita S, Takase H, Sugamoto Y, Arai A, Miura O, Mochizuki M. Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. Jpn J Ophthalmol 2009;53:209–214.

    Article  CAS  PubMed  Google Scholar 

  14. Miyanaga M, Sugita S, Shimizu N, et al. A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. Br J Ophthalmol 2010;94:336–340.

    Article  PubMed  Google Scholar 

  15. Mochizuki M, Watanabe T, Yamaguchi K, Tajima K. Human T-lymphotropic virus, type 1 associated disease. In: Pepose JS, Holland GN, Wilhelmus KR, editors. Ocular infection & immunology. St. Louis: Mosby-Year Book; 1996. p. 1366–1387.

    Google Scholar 

  16. Vatti R, Sharma OP. Course of asymptomatic liver involvement in sarcoidosis: role of therapy in selected cases. Sarcoidosis Vasc Diffuse Lung Dis 1997;14:73–76.

    CAS  PubMed  Google Scholar 

  17. Goto H, Mochizuki M, Yamaki K, Kotake S, Usui M, Ohno S. Epidemiological survey of intraocular inflammation in Japan. Jpn J Ophthalmol 2007;51:41–44.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Tokyo, Japan

    Hiroshi Takase, Kentarou Shimizu, Yukiko Yamada, Atsue Hanada, Hidemi Takahashi & Manabu Mochizuki

  2. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Manabu Mochizuki

Authors
  1. Hiroshi Takase
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kentarou Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yukiko Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Atsue Hanada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hidemi Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Manabu Mochizuki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Manabu Mochizuki.

About this article

Cite this article

Takase, H., Shimizu, K., Yamada, Y. et al. Validation of international criteria for the diagnosis of ocular sarcoidosis proposed by the first international workshop on ocular sarcoidosis. Jpn J Ophthalmol 54, 529–536 (2010). https://doi.org/10.1007/s10384-010-0873-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-010-0873-2

Keywords

Search

Navigation