Abstract
Perinephric fat stranding (PFS) is often detected on computed tomography (CT) in patients with acute pyelonephritis (APN). However, its clinical impact remains unclear. This study aimed to evaluate the clinical impact of PFS detected on CT in patients with APN. This retrospective observational study included patients with APN who underwent CT (median age, 79.5 years). Patients were classified into PFS (patients with PFS observed on CT) and non-PFS (patients without PFS observed on CT) groups, which were further classified into bacteraemia and non-bacteraemia groups. Clinical findings between the groups were compared. Among 194 patients who underwent CT, 111 (57.2%) patients demonstrated PFS. The rate of bacteraemia was significantly higher in the PFS group than in the non-PFS group (55.2 vs. 23.1%, p < 0.001). CT findings other than PFS were not associated with bacteraemia. The median peak body temperature was significantly higher in the PFS group than in the non-PFS group (38.8 vs. 38.5 °C, p < 0.001); however, the duration of fever and in-hospital mortality rates were not significantly different between the groups. Concordance between blood and urine culture results was observed in 75.0% of the patients; the presence of PFS was not different between patients with concordant and discordant results, regardless of the pre-treatment antibiotic used. Our findings suggest that the presence of PFS in patients with APN predicts bacteraemia; thus, clinicians should consider obtaining blood cultures if PFS is found on CT in patients with APN, even if the patients had received antibiotics prior to admission.
Similar content being viewed by others
References
Hooton TM, Stamm WE (1997) Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin N Am 11:551–581
Johnson JR, Russo TA (2018) Acute pyelonephritis in adults. N Engl J Med 378:48–59
Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG et al (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103–e120
Oh SJ, Je BK, Lee SH, Choi WS, Hong D, Kim SB (2016) Comparison of computed tomography findings between bacteremic and non-bacteremic acute pyelonephritis due to Escherichia coli. World J Radiol 8:403–409
Kim JS, Lee S, Lee KW, Kim JM, Kim YH, Kim ME (2014) Relationship between uncommon computed tomography findings and clinical aspects in patients with acute pyelonephritis. Korean J Urol 55:482–486
Fukami H, Takeuchi Y, Kagaya S, Ojima Y, Saito A, Sato H et al (2017) Perirenal fat stranding is not a powerful diagnostic tool for acute pyelonephritis. Int J Gen Med 10:137–144
Yu TY, Kim HR, Hwang KE, Lee JM, Cho JH, Lee JH (2016) Computed tomography findings associated with bacteremia in adult patients with a urinary tract infection. Eur J Clin Microbiol Infect Dis 35:1883–1887
Thanassi M (1997) Utility of urine and blood cultures in pyelonephritis. Acad Emerg Med 4:797–800
Hsu CY, Fang HC, Chou KJ, Chen CL, Lee PT, Chung HM (2006) The clinical impact of bacteremia in complicated acute pyelonephritis. Am J Med Sci 332:175–180
Kim Y, Seo MR, Kim SJ, Kim J, Wie SH, Cho YK et al (2017) Usefulness of blood cultures and radiologic imaging studies in the management of patients with community-acquired acute pyelonephritis. Infect Chemother 49:22–30
van der Starre WE, Zunder SM, Vollaard AM, Stalenhoef JE, Delfos NM, Spelt IC et al (2014) Prognostic value of pro-adrenomedullin, procalcitonin and C-reactive protein in predicting outcome of febrile urinary tract infection. Clin Microbiol Infect 20:1048–1054
Schwaber MJ, Carmeli Y (2007) Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J Antimicrob Chemother 60:913–920
Piccoli GB, Consiglio V, Deagostini MC, Serra M, Biolcati M, Ragni F et al (2011) The clinical and imaging presentation of acute “non complicated” pyelonephritis: a new profile for an ancient disease. BMC Nephrol 12:68
Buonaiuto VA, Marquez I, De Toro I, Joya C, Ruiz-Mesa JD, Seara R et al (2014) Clinical and epidemiological features and prognosis of complicated pyelonephritis: a prospective observational single hospital-based study. BMC Infect Dis 14:639
Weinstein MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G et al (1997) The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24:584–602
Spoorenberg V, Prins JM, Opmeer BC, de Reijke TM, Hulscher ME, Geerlings SE (2014) The additional value of blood cultures in patients with complicated urinary tract infections. Clin Microbiol Infect 20:O476–O479
Kim KS, Kim K, Jo YH, Kim TY, Lee JH, Lee SJ et al (2011) A simple model to predict bacteremia in women with acute pyelonephritis. J Inect 63:124–130
Kim Y, Wie SH, Chang UI, Kim J, Ki M, Cho YK et al (2014) Comparison of the clinical characteristics of diabetic and non-diabetic women with community-acquired acute pyelonephritis: a multicenter study. J Inect 69:244–251
van Nieuwkoop C, Bonten TN, van't Wout JW, Becker MJ, Groeneveld GH, Jansen CL et al (2010) Risk factors for bacteremia with uropathogen not cultured from urine in adults with febrile urinary tract infection. Clin Infect Dis 50:e69–e72
Karakonstantis S, Kalemaki D (2018) Blood culture useful only in selected patients with urinary tract infections—a literature review. Infect Dis (Lond) 50:584–592
Chen Y, Nitzan O, Saliba W, Chazan B, Colodner R, Raz R (2006) Are blood cultures necessary in the management of women with complicated pyelonephritis? J Inect 53:235–240
Velasco M, Martinez JA, Moreno-Martinez A, Horcajada JP, Ruiz J, Barranco M et al (2003) Blood cultures for women with uncomplicated acute pyelonephritis: are they necessary? Clin Infect Dis 37:1127–1130
Wing DA, Park AS, Debuque L, Millar LK (2000) Limited clinical utility of blood and urine cultures in the treatment of acute pyelonephritis during pregnancy. Am J Obstet Gynecol 182:1437–1440
Ledochowski S, Abraham PS, Jacob X, Dumitrescu O, Lina G, Lepape A et al (2015) Relevance of blood cultures in acute pyelonephritis in a single-center retrospective study. Intern Emerg Med 10:607–612
Dalhoff A (2012) Global fluoroquinolone resistance epidemiology and implictions for clinical use. Interdiscip Perspect Infect Dis 2012:976273
Talan DA, Krishnadasan A, Abrahamian FM, Stamm WE, Moran GJ, Group EMINS (2008) Prevalence and risk factor analysis of trimethoprim-sulfamethoxazole- and fluoroquinolone-resistant Escherichia coli infection among emergency department patients with pyelonephritis. Clin Infect Dis 47:1150–1158
Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'grady NP et al (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 49:1–45
Rollino C, Beltrame G, Ferro M, Quattrocchio G, Sandrone M, Quarello F (2012) Acute pyelonephritis in adults: a case series of 223 patients. Nephrol Dial Transplant 27:3488–3493
Foreman KJ, Marquez N, Dolgert A, Fukutaki K, Fullman N, McGaughey M et al (2018) Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories. Lancet 392:2052–2090
Acknowledgements
The authors thank the clinical staff at the General Internal Medicine and Family Medicine, Nabari City Hospital for their assistance in the completion of this study.
Contributions
RT designed the study, supervised the overall data collection process and wrote the manuscript. SI supported statistical data analysis. YT takes responsibility for the manuscript as a whole.
Funding
This work was supported by a grant from Mie University.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Tanizaki, R., Ichikawa, S. & Takemura, Y. Clinical impact of perinephric fat stranding detected on computed tomography in patients with acute pyelonephritis: a retrospective observational study. Eur J Clin Microbiol Infect Dis 38, 2185–2192 (2019). https://doi.org/10.1007/s10096-019-03662-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-019-03662-4