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Outcomes of endovascular treatment in acute ischemic stroke patients with current malignancy

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Abstract

Background and purposes

The role of endovascular recanalization in the treatment of cancer patients with acute stroke remains elusive. Our study aimed to investigate the clinical and imaging outcomes of endovascular recanalization treatment in patients with acute large vessel occlusion stroke who had active cancer.

Methods

We retrospectively reviewed the data from our stroke registry from January 2011 to September 2016 which was collected prospectively. Acute stroke patients with large artery occlusion in the anterior circulation who had active cancer were identified. Baseline clinical characteristics and postprocedural and long-term clinicoradiological outcomes were evaluated. A good outcome was defined as a 90-day modified Rankin Scale score of 0 to 2. Outcomes were also compared with those of non-malignancy patients who had received endovascular therapy during the same period.

Results

A total of 378 ischemic stroke patients received endovascular treatment, of whom 27 (7.14 %) had current malignancy. In patients with current malignancy, a low baseline NIHSS score and male sex were associated with functional independency at 90 days. When comparing with non-malignancy patients, no significant differences in the proportions of patients with symptomatic intracranial hemorrhage (11.1% vs 16.2%, p = 0.60) and good functional outcome (37.0% vs 39.6%, p = 0.84) were found in the malignancy patients.

Conclusion

Endovascular treatment might be a feasible therapeutic option for acute ischemic stroke patients with current malignancy when candidates are selected carefully because the outcomes were not differed. Future large-scale prospective studies are necessary.

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Funding source

This study was supported by a grant (CRI 16040-22) from Chonnam National University Hospital Biomedical Research Institute.

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Authors and Affiliations

  1. Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea

    Bang-Hoon Cho

  2. Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, South Korea

    Woong Yoon

  3. Department of Neurology, Chonnam National University Medical School and Hospital, 8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea

    Joon-Tae Kim, Kang-Ho Choi, Kyung-Wook Kang, Jin-Heui Lee, Ki-Hyun Cho & Man-Seok Park

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  1. Bang-Hoon Cho
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  2. Woong Yoon
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  3. Joon-Tae Kim
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  6. Jin-Heui Lee
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Correspondence to Man-Seok Park.

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The authors declare that they have no conflicts of interest.

Ethics statement

This study was approved by the institutional review board (IRB) of Chonnam National University Hospital. All clinical investigations described in this study were conducted in accordance with the principles expressed in the Declaration of Helsinki. Written informed consent was obtained from each patient or patient’s family member.

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Informed consent was obtained from all individual participants included in the study.

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Cho, BH., Yoon, W., Kim, JT. et al. Outcomes of endovascular treatment in acute ischemic stroke patients with current malignancy. Neurol Sci 41, 379–385 (2020). https://doi.org/10.1007/s10072-019-04103-y

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