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Clinical characteristics, pathological features and surgical outcomes of focal cortical dysplasia (FCD) type II: correlation with pathological subtypes

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Abstract

Focal cortical dysplasia (FCD) type II is a major cause of drug-resistant epilepsy. In order to gain insight into the possible correlations between FCD II pathological pattern and different clinical characteristics (including clinical information, imaging characteristics and surgical outcomes), different clinicopathological characteristics in two types of FCD II were analyzed (especially in FCD IIb). The mean age of seizure onset and disease duration of 78 patients was 11.0 and 11.2 years, respectively. Patients with FCD type IIb had earlier seizure onset compared with those with FCD type IIa. Pathological subtype IIb was predominantly in frontal lobe and subtype IIa was predominantly seen in temporal. Type IIb demonstrated significantly more signal abnormalities in fluid attenuated inversion recovery (FLAIR) images and T2 images than Type IIa. The rate of satisfactory seizure outcome was 67.64 % in the FCD IIa group, while relative higher, 88.63 %, in the FCD IIb group. All these characteristics may assist in their earlier diagnosis and improve the predictability of surgical management.

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Acknowledgments

This work was supported by the Open Research Fund of the Beijing Key Lab of Epilepsy Research (Grant No. 2013DXBL03), Beijing Municipal Natural Science Foundation (Grant No.7122088), Capital health research and development of special (Grant No. 2011-1020-01), Joint Fund for basic and clinical research cooperation project of Capital Medical University (Grant No. 12JL87) and Beijing Postdoctoral Research Foundation (Grant No. 2013ZZ-22). We would like to thank Dr. Wei Zhang, Ruili Ma, Mingwang Zhu and Na Li for their helpful discussions and suggestions.

Conflict of interest

The authors declare that they have no further financial or other conflicts of interest in relation to this research and its publication.

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Authors and Affiliations

  1. Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical University, Haidian District, Beijing, People’s Republic of China

    Kun Yao, Zejun Duan, Yu Bian, Zhong Ma & Xueling Qi

  2. Beijing Key Laboratory of Epilepsy, Beijing San Bo Brain Hospital, Capital Medical University, Haidian District, Beijing, People’s Republic of China

    Kun Yao & Xi Mei

  3. Department of Neurology, Beijing San Bo Brain Hospital, Capital Medical University, Haidian District, Beijing, People’s Republic of China

    Xi Mei & Xingzhou Liu

  4. Department of Neurosurgery (Ward I), Beijing San Bo Brain Hospital, Capital Medical University, Haidian District, Beijing, People’s Republic of China

    Changqing Liu

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  1. Kun Yao
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  2. Xi Mei
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  3. Xingzhou Liu
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  4. Zejun Duan
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  5. Changqing Liu
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  6. Yu Bian
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  7. Zhong Ma
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  8. Xueling Qi
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Corresponding author

Correspondence to Xueling Qi.

Additional information

K. Yao, X. Mei contributed equally to this work and manuscript writing.

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Yao, K., Mei, X., Liu, X. et al. Clinical characteristics, pathological features and surgical outcomes of focal cortical dysplasia (FCD) type II: correlation with pathological subtypes. Neurol Sci 35, 1519–1526 (2014). https://doi.org/10.1007/s10072-014-1782-9

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  • DOI: https://doi.org/10.1007/s10072-014-1782-9

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