Skip to main content
Log in

Antioxidative and anti-inflammatory activities of an ethanol extract from fig (Ficus carica) branches

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

The edible fruit of common fig (Ficus carica) or just the fig has been traditionally used for treating hemorrhoids, insect stings, gout, ulcers, and skin infections such as warts and viruses. An ethanol extract of fig branches and its ethyl acetate, hexane, butanol, and water fractions were prepared and examined for their abilities to scavenge free radicals and inhibit inflammatory reactions. Our data showed that the ethyl acetate fraction contained the largest amount of phenolic compounds and showed the highest free radical scavenging activity. Every fraction of fig, particularly the ethanol extract and the ethyl acetate and hexane fractions, inhibited nitric oxide production in RAW264.7 cells. Tumor necrosis factor-α level also decreased significantly in all groups tested. Our results demonstrate that fig branches possessed pharmacological activity and might be useful for developing antioxidant or antiinflammatory agents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Gond NY, Khadabadi SS. Hepatoprotective activity of Ficus carica leaf extract on rifampicin-induced hepatic damage in rats. Indian J. Pharm. Sci. 70: 364–366 (2008)

    Article  CAS  Google Scholar 

  2. Orhan IE, Ustun O, Sener B. Estimation of cholinesterase inhibitory and antioxidant effects of the leaf extracts of anatolian Ficus carica var. domestica and their total phenol and flavonoid contents. Nat. Prod. Commun. 6: 375–378 (2011)

    CAS  Google Scholar 

  3. Perez C, Canal JR, Campillo JE, Romero A, Torres MD. Hypotriglyceridaemic activity of Ficus carica leaves in experimental hypertriglyceridaemic rats. Phytother. Res. 13: 188–191 (1999)

    Article  CAS  Google Scholar 

  4. Lazreg Aref H, Gaaliche B, Fekih A, Mars M, Aouni M, Pierre Chaumon J, Said K. In vitro cytotoxic and antiviral activities of Ficus carica latex extracts. Nat. Prod. Res. 25: 310–319 (2011)

    Article  CAS  Google Scholar 

  5. Aref HL, Salah KB, Chaumont JP, Fekih A, Aouni M, Said K. In vitro antimicrobial activity of four Ficus carica latex fractions against resistant human pathogens (antimicrobial activity of Ficus carica latex). Pak. J. Pharm. Sci. 23: 53–58 (2010)

    Google Scholar 

  6. Bohlooli S, Mohebipoor A, Mohammadi S, Kouhnavard M, Pashapoor S. Comparative study of fig tree efficacy in the treatment of common warts (Verruca vulgaris) vs. cryotherapy. Int. J. Dermatol. 46: 524–526 (2007)

    Article  Google Scholar 

  7. Oliveira AP, Valentao P, Pereira JA, Silva BM, Tavares F, Andrade PB. Ficus carica L.: Metabolic and biological screening. Food Chem. Toxicol. 47: 2841–2846 (2009)

    Article  CAS  Google Scholar 

  8. Oliveira AP, Silva LR, Andrade PB, Valentao P, Silva BM, Goncalves RF, Pereira JA, Guedes de Pinho P. Further insight into the latex metabolite profile of Ficus carica. J. Agr. Food Chem. 58: 10855–10863 (2011)

    Article  Google Scholar 

  9. Oliveira AP, Silva LR, Ferreres F, Guedes de Pinho P, Valentao P, Silva BM, Pereira JA, Andrade PB. Chemical assessment and in vitro antioxidant capacity of Ficus carica latex. J. Agr. Food Chem. 58: 3393–3398 (2010)

    Article  CAS  Google Scholar 

  10. Richter G, Schwarz HP, Dorner F, Turecek PL. Activation and inactivation of human factor X by proteases derived from Ficus carica. Brit. J. Haematol. 119: 1042–1051 (2002)

    Article  CAS  Google Scholar 

  11. Rubnov S, Kashman Y, Rabinowitz R, Schlesinger M, Mechoulam R. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: Isolation and structure elucidation. J. Nat. Prod. 64: 993–996 (2001)

    Article  CAS  Google Scholar 

  12. Solomon A, Golubowicz S, Yablowicz Z, Grossman S, Bergman M, Gottlieb HE, Altman A, Kerem Z, Flaishman MA. Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). J. Agr. Food Chem. 54: 7717–7723 (2006)

    Article  CAS  Google Scholar 

  13. Vaya J, Mahmood S. Flavonoid content in leaf extracts of the fig (Ficus carica L.), carob (Ceratonia siliqua L.), and pistachio (Pistacia lentiscus L.). Biofactors 28: 169–175 (2006)

    Article  CAS  Google Scholar 

  14. Yang XM, Yu W, Ou ZP, Ma HL, Liu WM, Ji XL. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plant Food Hum. Nutr. 64: 167–173 (2009)

    Article  CAS  Google Scholar 

  15. Ali B, Mujeeb M, Aeri V, Mir SR, Faiyazuddin M, Shakeel F. Antiinflammatory and antioxidant activity of Ficus carica Linn. leaves. Nat. Prod. Res. 1: 1–6 (2011)

    Google Scholar 

  16. Chen LW, Cheng MJ, Peng CF, Chen IS. Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. Chem. Biodivers. 7: 1814–1821 (2007)

    Article  Google Scholar 

  17. Naressi MA, Ribeiro MA, Bersani-Amado CA, Zamuner ML, da Costa WF, Abe Tanaka CM, Sarragiotto MH. Chemical composition, anti-inflammatory, molluscicidal, and free-radical scavenging activities of the leaves of Ficus radicans ‘Variegata’ (Moraceae). Nat. Prod. Res. 1: 1–8 (2011)

    Google Scholar 

  18. Ramadan MA, Ahmad AS, Nafady AM, Mansour AI. Chemical composition of the stem bark and leaves of Ficus pandurata Hance. Nat. Prod. Res. 23: 1218–1230 (2009)

    Article  CAS  Google Scholar 

  19. el-Kholy IS, Shaban MA. Constituents of the leaves of Ficus carica L. II. Isolation of a psi-taraxasterylester, rutin, and a new steroid sapogenin. J. Chem. Soc. Perk. T. 1 13: 1140–1142 (1966)

    CAS  Google Scholar 

  20. Peana AT, Moretti MD, Manconi V, Desole G, Pippia P. Antiinflammatory activity of aqueous extracts and steroidal sapogenins of Agave americana. Planta Med. 63: 199–202 (1997)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hyeyoung Min.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Park, S., Han, J., Im, K. et al. Antioxidative and anti-inflammatory activities of an ethanol extract from fig (Ficus carica) branches. Food Sci Biotechnol 22, 1071–1075 (2013). https://doi.org/10.1007/s10068-013-0185-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-013-0185-7

Keywords

Navigation