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Factors associated with gout in South Koreans: analysis using the National Health Insurance Corporation and the National Health Screening Exam databases

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Abstract

The aim of this study was to identify the factors associated with gout among South Koreans. A case control study of gout patients newly diagnosed between January 1, 2007, and December 31, 2008, and matching controls was conducted using the nationwide database (National Health Insurance Corporation and National Health Screening Exam (NHSE) database), which included the health-care records of 48.1 million individuals. Of 495,998 newly diagnosed patients, we included 18,123 who were ≥40 years old and had an NHSE before diagnosis of gout. To elucidate the factors associated with gout, multivariate conditional logistic analyses were performed. Gout was associated with drinking ≥1/week (p < 0.001), drinking ≥1 bottle of soju/session (p < 0.001), high body mass index (BMI) (p < 0.001), high blood pressure (p < 0.001), high total cholesterol (p < 0.001), proteinuria (multivariate odds ratio (OR) = 1.75; 95 % confidence interval (CI) = 1.53–2.00), and an elevated uric acid (multivariate OR = 1.54; 95 % CI = 1.22–1.94). Exercise frequency was not significantly associated with gout. Prediabetic blood sugar level (100–125 mg/dL) was associated with gout in the univariate analysis, but not in the multivariate analysis. Diabetic blood sugar level (≥126 mg/dL) was associated with a decreased odds of gout (multivariate OR = 0.79; 95 % CI = 0.73–0.86). Our nationwide South Korean study showed that frequent and excessive alcohol consumption, high BMI, high blood pressure, high total cholesterol, proteinuria, and high uric acid are associated with gout.

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Acknowledgments

This study was supported by NHIC Ilsan Hospital Clinical Research Grant. We would like to give special thanks to the NHIC for allowing us to use NHIC and NHSE databases.

Disclosures

None.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 410-719, South Korea

    Chan Hee Lee

  2. Institute of Health Insurance and Clinical Research, National Health Insurance Corporation Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, South Korea

    Na Young Sung

  3. Cancer Early Detection Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, South Korea

    Na Young Sung

  4. Department of Biostatistics and Computing, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, South Korea

    Na Young Sung

  5. Division of Rheumatology, Department of Internal Medicine, Ewha Womans University School of Medicine, 911-1 Mok-dong, Yangcheon-gu, Seoul, South Korea

    Jisoo Lee

  6. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 17 Haengdang-dong, Seongdong-gu, Seoul, South Korea

    Sang-Cheol Bae

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  1. Chan Hee Lee
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Correspondence to Chan Hee Lee.

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Lee, C.H., Sung, N.Y., Lee, J. et al. Factors associated with gout in South Koreans: analysis using the National Health Insurance Corporation and the National Health Screening Exam databases. Clin Rheumatol 32, 829–837 (2013). https://doi.org/10.1007/s10067-013-2183-9

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  • DOI: https://doi.org/10.1007/s10067-013-2183-9

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