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The use of corticosteroid therapy in refractory Kawasaki patients

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Abstract

We retrospectively reviewed four children with Kawasaki disease refractory to the standard therapy. Although three patients had unusual complications, all four responded to intravenous methylprednisolone. This therapy may be considered early in the treatment of selected cases of Kawasaki disease.

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Abbreviations

IVIG:

Intravenous γ-globulin

IVMP:

Intravenous methylprednisolone

KD:

Kawasaki disease

References

  1. Wright D, Newburger J, Baker A, Sundel R (1996) Treatment of immune globulin-resistant Kawasaki disease with pulsed doses of corticosteroids. J Pediatr 128:146–149

    PubMed  Google Scholar 

  2. Shinorhara M, Sone K, Tomomasa T, Morikawa A (1999) Corticosteroids in the treatment of the acute phase of Kawasaki disease. J Pediatr 135:465–469

    PubMed  Google Scholar 

  3. Dale R, Saleem M, Daw S, Dillon M (2000) Treatment of severe complicated Kawasaki disease with oral prednisolone and aspirin. J Pediatr 137:723–726

    Article  CAS  PubMed  Google Scholar 

  4. Rauch A, Hurwitz E (1988) Centers for disease control case definition of Kawasaki syndrome. Pediatr Infect Dis J 142:441–444

    CAS  Google Scholar 

  5. Al-Eid W, Jefri A, Bahabri S, Al-Mayouf SM (2000) Haemophagocytosis in complicating Kawasaki disease. J Pediatr Hematol Oncol 17:323–329

    Article  CAS  Google Scholar 

  6. Terai M, Shulman S (1997) Prevalence of coronary artery abnormalities in Kawasaki disease is highly dependent on gamma globulin dose but independent of salicylate dose. J Pediatr 131:888–893

    CAS  PubMed  Google Scholar 

  7. Newburger J, Takahashi M, Beiser A et al. (1991) A single intravenous infusion of gamma globulin as compared with four in fusions in the treatment in Kawasaki disease. N Engl J Med 324:1633–1639

    PubMed  Google Scholar 

  8. Chang J, Lín J, Peng C, Tsai C (1999) Kawasaki disease complicated by peripheral gangrene. Pediatr Cardiol 20:139–142

    Article  CAS  PubMed  Google Scholar 

  9. Sundel R, Burns J Baker A, Beiser A, Newburger J (1993) Gamma globulin re-treatment in Kawasaki disease. J Pediatr 123:657–659

    PubMed  Google Scholar 

  10. Burns J, Capparelli E, Brown J, Newburger J, Glode M (1998) Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. Pediatr Infect Dis J 17:1144–1148

    Article  CAS  PubMed  Google Scholar 

  11. Kato H, Koike S, Yokoyome T (1979) Kawasaki disease: effect of treatment on coronary involvement. Pediatrics 63:175–179

    CAS  PubMed  Google Scholar 

  12. Trumble T, Fitch R (1986) Kawasaki disease– A cause of vasculitis in children. J Pediatr Orthop 6:92–95

    CAS  PubMed  Google Scholar 

  13. Ohga S, Ooshima A, Fukushige J, Ueda K (1995) Histocytic haemophagocytosis in a patient with Kawasaki disease: changes in the hypercytokinaemic state. Eur J Pediatr 154:539–541

    CAS  PubMed  Google Scholar 

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Correspondence to Sulaiman M. Al-Mayouf.

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Al-Mayouf, S.M. The use of corticosteroid therapy in refractory Kawasaki patients. Clin Rheumatol 23, 11–13 (2004). https://doi.org/10.1007/s10067-003-0752-z

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  • DOI: https://doi.org/10.1007/s10067-003-0752-z

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