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A case of primary diffuse leptomeningeal gliomatosis

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Abstract

Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease characterized by diffuse infiltration of the leptomeninges by neoplastic glial cells without evidence of tumor in the brain parenchyma or spinal cord. We report a 60-year-old man with PDLG. He suffered transient right hemiparesis and generalized seizures. MRI showed diffuse leptomeningeal thickening and enhancement throughout the brain and spinal cord without any intraaxial involvement. Biopsy resulted in a diagnosis of glioblastoma with methylated MGMT promoter and wild-type IDH1. He underwent craniospinal radiotherapy and temozolomide treatment but despite concomitant adjuvant therapy he died 8 months after initial presentation.

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Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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Authors and Affiliations

  1. Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan

    Kouji Yamasaki, Kiyotaka Yokogami, Shinji Yamashita, Hisao Uehara & Hideo Takeshima

  2. Department of Neurosurgery, Miyakonojo Medical Association Hospital, Miyazaki, Japan

    Hajime Ohta

  3. Department of Pathology, Faculty of Medicine, University Miyazaki, Miyazaki, Japan

    Yuichiro Sato

Authors
  1. Kouji Yamasaki
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  2. Kiyotaka Yokogami
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  3. Hajime Ohta
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  4. Shinji Yamashita
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  5. Hisao Uehara
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  6. Yuichiro Sato
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  7. Hideo Takeshima
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Corresponding author

Correspondence to Kouji Yamasaki.

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Yamasaki, K., Yokogami, K., Ohta, H. et al. A case of primary diffuse leptomeningeal gliomatosis. Brain Tumor Pathol 31, 177–181 (2014). https://doi.org/10.1007/s10014-014-0176-2

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  • DOI: https://doi.org/10.1007/s10014-014-0176-2

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