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Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women: associated factors and birth-cohort effect. The Taiji Study

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Abstract

We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40–79 years; 50 of each gender and age stratum) from a list of registered residents in 1993. We measured BMD of the spine and hip, and serum concentrations of total osteocalcin (OC), beta-C-terminal cross-linking telopeptide of type I collagen (beta-CTX), and N-terminal cross-linking telopeptide of type I collagen (NTX), in 1993 and 2003. Of the 400 subjects, 322 (153 men, 169 women) completed the 10-year follow-up. Mean change rates (standard deviation) for serum total OC, beta-CTX, and NTX over 10 years were –1.00 (3.74)%/year, 5.10 (22.48)%/year, and 0.40 (3.41)%/year, respectively, in men, and 0.02 (5.32)%/year, 5.53 (14.54)%/year, and 0.62 (3.26)%/year, respectively, in women. Change rates of BTMs were higher for women in their forties than for women in their fifties to seventies (P < 0.05), and higher in the menstrual transition group than in pre- and postmenopausal groups (P < 0.001). Changes in levels of BTMs over 10 years in women were significantly associated with change rates of BMDs at L2–L4 and total hip after adjusting for potential confounders. A significant birth-cohort effect was observed among women in their fifties. We concluded that change rates of BTMs during the 10 years were influenced by menstrual transition, age, and sex and associated with bone loss at L2–L4 and total hip.

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Acknowledgments

This work was supported by the following Grants-in-Aid for Scientific Research: B20390182 (Noriko Yoshimura), C20591737 (Toru Akune), C20591774 (Shigeyuki Muraki), Young Scientists A18689031 (Hiroyuki Oka), and Collaborating Research with NSF 08033011-00262 (Director, Noriko Yoshimura) from the Ministry of Education, Culture, Sports, Science and Technology; H17-Men-eki-009 (Director, Kozo Nakamura), H18-Choujyu-037 (Director, Toshitaka Nakamura), and H20-Choujyu-009 (Director, Noriko Yoshimura) from the Ministry of Health, Labour and Welfare in Japan. This study was also supported by grants from the Japan Osteoporosis Society (Noriko Yoshimura), Nakatomi Foundation (Noriko Yoshimura), and research aid from the Japanese Orthopaedic Association (JOA-Subsidized Science Project Research 2006-1, Director, Hiroshi Kawaguchi). The sponsors had no role in the study design, data collection, data analysis, data interpretation, or writing of this report. The authors wish to thank Mrs. Tamako Tsutsumi, Mrs. Kanami Maeda, and other members of the Public Office in Taiji Town and members of the Public Health Center in Shingu City for their assistance in locating and scheduling participants for examinations.

Conflict of interest

The authors have no conflicts or disclosures to declare regarding the present manuscript.

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Authors and Affiliations

  1. Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Noriko Yoshimura & Hiroyuki Oka

  2. Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Shigeyuki Muraki & Toru Akune

  3. Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    Hiroshi Kawaguchi & Kozo Nakamura

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  1. Noriko Yoshimura
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  2. Shigeyuki Muraki
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  3. Hiroyuki Oka
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  4. Hiroshi Kawaguchi
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  5. Kozo Nakamura
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  6. Toru Akune
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Correspondence to Noriko Yoshimura.

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Yoshimura, N., Muraki, S., Oka, H. et al. Changes in serum levels of biochemical markers of bone turnover during 10 years among Japanese men and women: associated factors and birth-cohort effect. The Taiji Study. J Bone Miner Metab 29, 699–708 (2011). https://doi.org/10.1007/s00774-011-0266-8

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  • DOI: https://doi.org/10.1007/s00774-011-0266-8

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