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High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia

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Summary.

Serum samples obtained from 289 first-time and 114 repeat donors at the Blood Center of Mongolia (MBC) were tested for serological and molecular markers of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections. Among the 403 blood donors, 33 (8.2%), 21 (5.2%), and 27 (6.7%) tested positive for hepatitis B surface antigen (HBsAg) and/or HBV DNA, HCV RNA, and HDV RNA, respectively. Collectively, 55 donors were viremic for one or more of these viruses, and included 54 first-time donors (18.7%) and 1 repeat donor (0.9%) (P < 0.0001). One discrepant case with HBsAg detectable only at MBC was negative for HBsAg, HBV DNA and anti-HBc in this study. Four donors who were HCV-viremic in this study were negative for anti-HCV by the MBC method. Further efforts to increase the sensitivity and specificity of the currently-used tests are urgently required in Mongolia. Three donors who were positive for anti-HBc and anti-HDV but negative for HBsAg, had both HBV DNA and HDV RNA. This suggests that introduction of a new anti-HDV serological test is useful for not only HDV screening but also HBV screening of anti-HBc-positive, HBsAg negative donors, considering a possibility of viral interference by coexisting HDV.

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References

  • E Alestig C Hannoun P Horal M Lindh (2001) ArticleTitleHepatitis B virus genotypes in Mongols and Australian Aborigines. Arch Virol 146 2321–2329 Occurrence Handle10.1007/s007050170005 Occurrence Handle11811682 Occurrence Handle1:CAS:528:DC%2BD38Xjs12ks7Y%3D

    Article  PubMed  CAS  Google Scholar 

  • JL Casey TL Brown EJ Colan FS Wignall JL Gerin (1993) ArticleTitleA genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci USA 90 9016–9020 Occurrence Handle8415646 Occurrence Handle1:CAS:528:DyaK2cXhsFGhsro%3D

    PubMed  CAS  Google Scholar 

  • HP Dienes RH Purcell H Popper A Ponzetto (1990) ArticleTitleThe significance of infections with two types of viral hepatitis demonstrated by histologic features in chimpanzees. J Hepatol 10 77–84 Occurrence Handle10.1016/0168-8278(90)90076-4 Occurrence Handle2106549 Occurrence Handle1:STN:280:By%2BC2s7kvVQ%3D

    Article  PubMed  CAS  Google Scholar 

  • JR Ebright T Altantsetseg R Oyungerel (2003) ArticleTitleEmerging infectious diseases in Mongolia. Emerg Infect Dis 9 1509–1515 Occurrence Handle14720388

    PubMed  Google Scholar 

  • JS Edstam N Dulmaa P Nymadawa A Rinchin J Khulan AM Kimball (2002) ArticleTitleComparison of hepatitis B vaccine coverage and effectiveness among urban and rural Mongolian 2-year-olds. Prev Med 34 207–214 Occurrence Handle10.1006/pmed.2001.0972 Occurrence Handle11817916

    Article  PubMed  Google Scholar 

  • SR Emmett B Dove L Mahoney T Wurm JA Hiscox (2005) ArticleTitleThe cell cycle and virus infection. Methods Mol Biol 296 197–218 Occurrence Handle15576934 Occurrence Handle1:CAS:528:DC%2BD2MXkt12rtL0%3D

    PubMed  CAS  Google Scholar 

  • J Felsenstein (1985) ArticleTitleConfidence limits on phylogenies: an approach using the bootstrap. Evolution 39 783–791

    Google Scholar 

  • S Fujioka H Shimomura Y Ishii J Kondo K Fujio F Ikeda M Miyake S Kusachi T Tsuji (1998) ArticleTitlePrevalence of hepatitis B and C virus markers in outpatients of Mongolian general hospitals. Kansenshogaku Zasshi 72 5–11 Occurrence Handle9503777 Occurrence Handle1:STN:280:DyaK1c7msVGhug%3D%3D

    PubMed  CAS  Google Scholar 

  • GB Gaeta T Stroffolini M Chiaramonte T Ascione G Stornaiuolo S Lobello E Sagnelli MR Brunetto M Rizzetto (2003) ArticleTitleChronic hepatitis D: a vanishing disease? An Italian multicenter study. Hepatology 32 824–827

    Google Scholar 

  • TI Huo JC Wu SI Wu AL Chang SK Lin CH Pan YH Huang FY Chang SD Lee (2004) ArticleTitleChanging seroepidemiology of hepatitis B, C, and D virus infections in high-risk populations. J Med Virol 72 41–45 Occurrence Handle10.1002/jmv.10554 Occurrence Handle14635009

    Article  PubMed  Google Scholar 

  • H Iizuka K Ohmura A Ishijima K Satoh T Tanaka F Tsuda H Okamoto Y Miyakawa M Mayumi (1992) ArticleTitleCorrelation between anti-HBc titers and HBV DNA in blood units without detectable HBsAg. Vox Sang 63 107–111 Occurrence Handle1441302 Occurrence Handle1:STN:280:ByyD2s%2Fgslw%3D Occurrence Handle10.1111/j.1423-0410.1992.tb02495.x

    Article  PubMed  CAS  Google Scholar 

  • Y Ina (1994) ArticleTitleODEN: a program package for molecular evolutionary analysis and database search of DNA and amino acid sequences. Comput Appl Biosci 10 11–12 Occurrence Handle8193950 Occurrence Handle1:CAS:528:DyaK2cXksFKls7s%3D

    PubMed  CAS  Google Scholar 

  • J Inoue M Takahashi T Nishizawa L Narantuya M Sakuma Y Kagawa T Shimosegawa H Okamoto (2005) ArticleTitleHigh prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia. J Med Virol 76 333–340 Occurrence Handle10.1002/jmv.20363 Occurrence Handle15902700 Occurrence Handle1:CAS:528:DC%2BD2MXlslKiu70%3D

    Article  PubMed  CAS  Google Scholar 

  • InstitutionalAuthorNameJapanese Red Cross Non-A, Non-B Hepatitis Research Group (1991) ArticleTitleEffect of screening for hepatitis C virus antibody and hepatitis B virus core antibody on incidence of post-transfusion hepatitis. Lancet 338 1040–1041

    Google Scholar 

  • R Jardi F Rodriguez M Buti X Costa M Cotrina R Galimany R Esteban J Guardia (2001) ArticleTitleRole of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference. Hepatology 34 404–410 Occurrence Handle10.1053/jhep.2001.26511 Occurrence Handle11481626 Occurrence Handle1:CAS:528:DC%2BD3MXmtVGqtLg%3D

    Article  PubMed  CAS  Google Scholar 

  • Y Kondo M Mizokami T Nakano T Kato R Ueda M Mukaide K Hikiji T Ishida D Dorjsuren B Dashnyam T Oyunsuren (1997) ArticleTitlePrevalence and molecular epidemiology of GB virus C/hepatitis G virus infection in Mongolia. J Med Virol 52 143–148 Occurrence Handle10.1002/(SICI)1096-9071(199706)52:2<143::AID-JMV4>3.0.CO;2-3 Occurrence Handle9179759 Occurrence Handle1:CAS:528:DyaK2sXjvFyks78%3D

    Article  PubMed  CAS  Google Scholar 

  • M Kuhns A McNamara A Mason C Campbell R Perrillo (1992) ArticleTitleSerum and liver hepatitis B virus DNA in chronic hepatitis B after sustained loss of surface antigen. Gastroenterology 103 1649–1656 Occurrence Handle1385254 Occurrence Handle1:STN:280:ByyD2M7gvVI%3D

    PubMed  CAS  Google Scholar 

  • K Lo GT Sheu MM Lai (1998) ArticleTitleInhibition of cellular RNA polymerase II transcription by delta antigen of hepatitis delta virus. Virology 247 178–188 Occurrence Handle10.1006/viro.1998.9253 Occurrence Handle9705911 Occurrence Handle1:CAS:528:DyaK1cXlt1ehtr0%3D

    Article  PubMed  CAS  Google Scholar 

  • DK Lvov EI Samokhvalov F Tsuda NA Selivanov H Okamoto VM Stakhanova IV Stakhgildyan NV Doroshenko TL Yashina SN Kuzin IA Suetina PG Deryabin LA Ruzaeva VN Bezgodov LA Firsova SN Sorinson S Mishiro (1996) ArticleTitlePrevalence of hepatitis C virus and distribution of its genotypes in Northern Eurasia. Arch Virol 141 1613–1622 Occurrence Handle8893785 Occurrence Handle1:CAS:528:DyaK28XmvVChtbo%3D

    PubMed  CAS  Google Scholar 

  • S Makino MF Chang CK Shieh T Kamahora DM Vannier S Govindarajan MM Lai (1987) ArticleTitleMolecular cloning and sequencing of a human hepatitis delta (δ) virus RNA. Nature 329 343–346 Occurrence Handle10.1038/329343a0 Occurrence Handle3627276 Occurrence Handle1:CAS:528:DyaL1cXmvFOltw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  • TI Michalak C Pasquinelli S Guilhot FV Chisari (1994) ArticleTitleHepatitis B virus persistence after recovery from acute viral hepatitis. J Clin Invest 93 230–239 Occurrence Handle8282792 Occurrence Handle1:STN:280:ByuC3M%2Fjt10%3D Occurrence Handle10.1172/JCI116950

    Article  PubMed  CAS  Google Scholar 

  • LE Modahl MM Lai (2000) ArticleTitleThe large delta antigen of hepatitis delta virus potently inhibits genomic but not antigenomic RNA synthesis: a mechanism enabling initiation of viral replication. J Virol 74 7375–7380 Occurrence Handle10.1128/JVI.74.16.7375-7380.2000 Occurrence Handle10906190 Occurrence Handle1:CAS:528:DC%2BD3cXlt1GrsrY%3D

    Article  PubMed  CAS  Google Scholar 

  • K Nishioka (1996) ArticleTitleTransfusion-transmitted HBV and HCV. Vox Sang 70 IssueID[Suppl 3] 4–6

    Google Scholar 

  • Nymadawa P (2002) Health Sector 2002: reducing maternal mortality. Ulaanbaatar, Ministry of Health of Mongolia

  • H Okamoto H Tokita M Sakamoto M Horikita M Kojima H Iizuka S Mishiro (1993) ArticleTitleCharacterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection. J Gen Virol 74 2385–2390 Occurrence Handle7504073 Occurrence Handle1:CAS:528:DyaK2cXhvVChtr8%3D

    PubMed  CAS  Google Scholar 

  • H Okamoto S Mishiro H Tokita F Tsuda Y Miyakawa M Mayumi (1994) ArticleTitleSuperinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a. Hepatology 20 1131–1136 Occurrence Handle7927243 Occurrence Handle1:STN:280:ByqD3M3ht1A%3D

    PubMed  CAS  Google Scholar 

  • H Okamoto S Kobata H Tokita T Inoue GD Woodfield PV Holland BA Al-Knawy O Uzunalimoglu Y Miyakawa M Mayumi (1996) ArticleTitleA second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene. J Virol Methods 57 31–45 Occurrence Handle10.1016/0166-0934(95)01960-X Occurrence Handle8919822 Occurrence Handle1:CAS:528:DyaK28Xhslensbs%3D

    Article  PubMed  CAS  Google Scholar 

  • Oyunbileg L, Ulaankhuu D, Altangerel W, Naranchimeg L, Oyunbold D (2004) Result of screening of Mongolian blood donors for the markers of transfusion-transmitted virus infections. The Tenth National Conference on Current Topics of Virology, Ulaanbaatar, Mongolia (Abstract), p 134

  • A Quintero N Uzcategui CL Loureiro L Villegas X Illarramendi ME Guevara JE Ludert L Blitz F Liprandi FH Pujol (2001) ArticleTitleHepatitis delta virus genotypes I and III circulate associated with hepatitis B virus genotype F in Venezuela. J Med Virol 64 356–359 Occurrence Handle10.1002/jmv.1058 Occurrence Handle11424126 Occurrence Handle1:CAS:528:DC%2BD3MXlvVant7w%3D

    Article  PubMed  CAS  Google Scholar 

  • B Rehermann C Ferrari C Pasquinelli FV Chisari (1996) ArticleTitleThe hepatitis B virus persists for decades after patients recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 2 1104–1108 Occurrence Handle10.1038/nm1096-1104 Occurrence Handle8837608 Occurrence Handle1:CAS:528:DyaK28Xmt1Wnu7s%3D

    Article  PubMed  CAS  Google Scholar 

  • M Rizzetto MG Canese S Arico O Crivelli C Trepo F Bonino G Verme (1977) ArticleTitleImmunofluorescence detection of new antigen-antibody system (δ anti-δ) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut 18 997–1003 Occurrence Handle75123 Occurrence Handle1:STN:280:DyaE1c7gsl2jtg%3D%3D

    PubMed  CAS  Google Scholar 

  • N Saitou M Nei (1987) ArticleTitleThe neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4 406–425 Occurrence Handle3447015 Occurrence Handle1:STN:280:BieC1cbgtVY%3D

    PubMed  CAS  Google Scholar 

  • N Saudy F Sugauchi Y Tanaka S Suzuki AA Aal MA Zaid S Agha M Mizokami (2003) ArticleTitleGenotypes and phylogenetic characterization of hepatitis B and delta viruses in Egypt. J Med Virol 70 529–536 Occurrence Handle10.1002/jmv.10427 Occurrence Handle12794714 Occurrence Handle1:CAS:528:DC%2BD3sXlslOmsLg%3D

    Article  PubMed  CAS  Google Scholar 

  • C Sureau B Guerra RE Lanford (1993) ArticleTitleRole of the large hepatitis B virus envelope protein in infectivity of the hepatitis delta virion. J Virol 67 366–372 Occurrence Handle8416375 Occurrence Handle1:CAS:528:DyaK3sXlsleitA%3D%3D

    PubMed  CAS  Google Scholar 

  • M Takahashi T Nishizawa Y Gotanda F Tsuda F Komatsu T Kawabata K Hasegawa M Altankhuu U Chimedregzen L Narantuya H Hoshino K Hino Y Kagawa H Okamoto (2004) ArticleTitleHigh prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C, and D viruses among apparently healthy populations in Mongolia. Clin Diagn Lab Immunol 11 392–398 Occurrence Handle10.1128/CDLI.11.2.392-398.2004 Occurrence Handle15013993

    Article  PubMed  Google Scholar 

  • M Takahashi S Kusakai H Mizuo K Suzuki K Fujimura K Masuko Y Sugai T Aikawa T Nishizawa H Okamoto (2005) ArticleTitleSimultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection. J Clin Microbiol 43 49–56 Occurrence Handle15634950 Occurrence Handle1:CAS:528:DC%2BD2MXhtF2ntL4%3D

    PubMed  CAS  Google Scholar 

  • KS Wang QL Choo AJ Weiner JH Ou RC Najarian RM Thayer GT Mullenbach KJ Denniston JL Gerin M Houghton (1986) ArticleTitleStructure, sequence and expression of the hepatitis delta (δ) viral genome. Nature 323 508–514 Occurrence Handle3762705 Occurrence Handle1:CAS:528:DyaL2sXivVehsw%3D%3D

    PubMed  CAS  Google Scholar 

  • JC Wu PJ Chen MY Kuo SD Lee DS Chen LP Ting (1991) ArticleTitleProduction of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line. J Virol 65 1099–1104 Occurrence Handle1847439 Occurrence Handle1:CAS:528:DyaK3MXhtFygu7k%3D

    PubMed  CAS  Google Scholar 

  • JW Yewdell AB Hill (2002) ArticleTitleViral interference with antigen presentation. Nat Immunol 3 1019–1025 Occurrence Handle10.1038/ni1102-1019 Occurrence Handle12407410 Occurrence Handle1:CAS:528:DC%2BD38Xot1Chsr8%3D

    Article  PubMed  CAS  Google Scholar 

  • H Zaki GL Darmstadt A Baten CR Ahsan SK Saha (2003) ArticleTitleSeroepidemiology of hepatitis B and delta virus infections in Bangladesh. J Trop Pediatr 49 371–374 Occurrence Handle14725415

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Virology, Department of Infection and Immunity, Jichi Medical School, Tochigi-Ken, Japan

    B. Tsatsralt-Od, M. Takahashi, T. Nishizawa, J. Inoue & H. Okamoto

  2. Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan

    J. Inoue

  3. Blood Center of Mongolia, Ulaanbaatar, Mongolia

    D. Ulaankhuu

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  1. B. Tsatsralt-Od
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  2. M. Takahashi
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  3. T. Nishizawa
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  4. J. Inoue
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  5. D. Ulaankhuu
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  6. H. Okamoto
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Tsatsralt-Od, B., Takahashi, M., Nishizawa, T. et al. High prevalence of hepatitis B, C and delta virus infections among blood donors in Mongolia. Arch Virol 150, 2513–2528 (2005). https://doi.org/10.1007/s00705-005-0590-1

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