Abstract
Purpose
Primary squamous cell carcinoma (SCC) and metaplastic squamous cell carcinoma (MSCC) are rare types of breast cancer with specific histological features. They are characterized by rapid progression, a tendency toward cyst formation, and negativity for hormone receptors. Many studies have concluded that SCC of the breast carries a poor prognosis, based on the fact that conventional chemotherapy for ductal carcinoma of the breast is ineffective against SCC. This is a retrospective study of patients in a single center with SCC or MSCC.
Methods
We searched the records of the Tokyo Metropolitan Komagome Hospital for patients diagnosed with breast SCC or MSCC between 1979 and 2006. Squamous cell carcinoma was diagnosed when 100% of the malignant cells showed a squamous component (pure SCC) and MSCC was diagnosed when more than 50% of the malignant cells showed a squamous component. We analyzed the clinicopathological features, treatment methods, and outcomes of these patients.
Results
We identified 10 (0.28%) patients with SCC or MSCC from among 3565 patients with malignant breast tumors treated at our hospital during this period. Nine patients had adenocarcinoma with squamous metaplasia, and one had pure SCC. Ultrasound showed a central cystic-necrotic component in seven tumors, and all of the tumors were negative for hormone receptors and HER2. Recurrence developed in two patients with lymph node metastasis, but not in the other eight patients. The 5-year survival rate and median survival time were 85.7% and 97 months, respectively.
Conclusions
Squamous cell carcinoma or MSCC of the breast with features of the triple-negative subtype seems to be associated with a poor prognosis; however, nodenegative patients are likely to have a favorable prognosis.
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References
The Japanese Breast Cancer Society. oGeneral rules for clinical and pathological recording of breast cancer. 15th ed. Tokyo: Kanehara; June 2004.
Hennessy BT, Krishnamurthy S, Giordano S, Buchholz TA, Kau SW, Duan Z, et al. Squamous cell carcinoma of the breast. J Clin Oncol 2005;23(31):7827–7835.
Kaise H, Sakamoto G, Akiyama F, Kasumi F, Yoshimoto M. A clinicopathological study of 22 primary squamous cell carcinomas of the breast. Jpn J Breast Cancer 2000;15(2):178–182.
Kurumiya Y, Terasaki M, Okamoto Y, Gotoh Y, Asaba Y, Niimiya Y, et al. Squamous cell carcinoma of the breast, a study of 145 cases in the domestic literature with 4 cases of our hospital (in Japanese). Surgery 2003;65(9):1088–1092.
Sakurai K, Okamura H, Enomoto K, Nezu K, Wakabayashi K, Miyake H, et al. Two cases of primary pure squamous cell carcinoma of the breast. J Nihon Univ Med Assoc 2003;62(12):673–676.
Cardoso F, Leal C, Meira A, Azevedo R, Mauricio MJ, Lopes C, et al. Squamous cell carcinoma of the breast. Breast 2000;9:315–319.
Eggers JW, Chesney T. Squamous cell carcinoma of the breast: a clinicopathologic analysis of eight cases and review of literature. Hum Pathol 1984;15:526–531.
Stevenson JT, Graham DJ, Khiyami A, Mansour EG. Squamous cell carcinoma of the breast; a clinical approach. Ann Surg Oncol 1996;3:367–374.
Toikkanen S. Primary squamous cell carcinoma of the breast. Cancer 1981;48:1629–1632.
Hachiya H, Ishida T, Kurosumi M, Yokoe T, Ogawa T, Iino Y. A clinicopathological study of 7 primary squamous cell carcinoma of breast (in Japanese). Jpn J Breast Cancer 1988;3(4):565–569.
Shigekawa T, Tsuda H, Sato K, Ueda S, Asakawa H, Shigenaga R, et al. Squamous cell carcinoma of the breast in the form of an intracystic tumor. Breast Cancer 2007;14(1):109–112.
Aparicio I, Martinez A, Hernandez G, Hardisson D, De Santiago J. Squamous cell carcinoma of breast. Eur J Obstet Gynecol Reprod Biol 2008;137(2)222–226.
Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V, et al. Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast. Anticancer Res 2007;27(1B):547–555.
Behranwala KA, Nasiri N, Abdullah N, Trott PA, Gui GP. Squamous cell carcinoma of the breast: clinico-pathologic implications and outcome. Eur J Surg Oncol 2003;29(4):386–389.
Brack K, Ramaekers PC, Tjalma WA. Primary squamous cell carcinoma of the breast. Eur J Gynaecol Oncol 2003;24(5):384–386.
Hiramatsu K, Kato K, Hirata A, Matsuba H, Hara T, Ito T, et al. A resected case of squamous cell carcinoma of the breast successfully treated by FU plus cisplatin (CDDP) adjuvant therapy against recurrent metastases. Jpn J Cancer Chemother 2007;34(3):443–446.
Dejager D, Philip RN, Anne DM, Davis HL, Komorowski RA. Primary squamous cell carcinoma of the breast: Sensitivity to cisplatinum-based chemotherapy. J Surg Oncol 1995;59(3):199–203.
Miura H, Taira O, Hiraguri S, Maeda J, Kato H. Recurrent squamous cell carcinoma of the breast with undifferentiated features: report of a case. Surg Today 2002;32(10):891–895.
Farrand R, Lavigne R, Lokich J. Epidermoid carcinoma of the breast. J Surg Oncol 1979;12:207–211.
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Honda, M., Saji, S., Horiguchi, SI. et al. Clinicopathological analysis of ten patients with metaplastic squamous cell carcinoma of the breast. Surg Today 41, 328–332 (2011). https://doi.org/10.1007/s00595-009-4276-2
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DOI: https://doi.org/10.1007/s00595-009-4276-2