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Endoscopic ultrasound-guided fine-needle aspiration in patients with lymphadenopathy suspected of recurrent malignancy after curative treatment

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Abstract

Background

The diagnosis of lymphadenopathy after treatment of malignancy is sometimes difficult, especially in patients whose treatment was deemed curative and without local recurrence or those who have increased serum levels of related tumor markers. We aimed to evaluate the effectiveness of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) as a diagnostic tool in patients with lymphadenopathy after curative treatment of malignancy.

Methods

Consecutive patients with mediastinal, intraabdominal, or pelvic lymphadenopathy after curative treatment of malignancy who were referred to our hospital between October 2003 and September 2007 were enrolled in this study.

Results

A total of 62 patients were included. The lymph nodes were located at the mediastinum in 22 patients, intraabdomen in 38 patients, and intrapelvis in 2 patients. From the pathological findings of the FNA sample, 31 patients (50%) were confirmed to have recurrence of the prior malignancy, and 9 patients (15%) were diagnosed as having a different new malignancy. The remaining 22 patients (35%) were shown to have no recurrence or no other malignancies. However, 1 of them was later diagnosed with recurrence by open laparotomy. The overall sensitivity, specificity, accuracy, and positive and negative predictive values of the EUS-FNA were 97%, 100%, 98%, 100%, and 97%, respectively.

Conclusions

Lymphadenopathy after treatment of malignancy is not a definitive sign of recurrence. Therefore, pathological sampling and diagnosis are essential for determining the appropriate treatment. For this purpose, EUS-FNA is a safe, convenient, and minimally invasive procedure with high diagnostic value.

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Authors and Affiliations

  1. First Department of Internal Medicine, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan

    Takuji Iwashita, Ichiro Yasuda, Shinpei Doi, Masanori Nakashima, Hisashi Tsurumi & Hisataka Moriwaki

  2. Department of Clinical Pathology, Gifu University Hospital, Gifu, Japan

    Yoshinobu Hirose

  3. Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan

    Tsuyoshi Takami

  4. Department of Gastroenterology, Gifu Municipal Hospital, Gifu, Japan

    Masamichi Enya, Tsuyoshi Mukai, Takaya Ohnishi, Keisuke Iwata & Eiichi Tomita

Authors
  1. Takuji Iwashita
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  2. Ichiro Yasuda
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  3. Shinpei Doi
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  4. Masanori Nakashima
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  7. Tsuyoshi Takami
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  8. Masamichi Enya
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  11. Keisuke Iwata
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  12. Eiichi Tomita
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  13. Hisataka Moriwaki
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Iwashita, T., Yasuda, I., Doi, S. et al. Endoscopic ultrasound-guided fine-needle aspiration in patients with lymphadenopathy suspected of recurrent malignancy after curative treatment. J Gastroenterol 44, 190–196 (2009). https://doi.org/10.1007/s00535-008-2302-6

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  • DOI: https://doi.org/10.1007/s00535-008-2302-6

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