Abstract
Background. This study investigated the influence of feeding on gastric acid suppression in Helicobacter pylori-positive patients treated with intravenous infusions of proton pump inhibitors (PPIs) or with H2-receptor antagonists (H2-RAs) after bleeding from a gastric ulcer. Methods. Forty-nine H. pylori-positive patients with bleeding gastric ulcers (44 men and 5 women) were divided into four groups: one group received an H2-RA while fasting, one group received an H2-RA while eating regularly, one group received a PPI while fasting, and one group received a PPI while eating regularly. Intragastric pH was monitored during fasting and nonfasting to calculate the pH 3 and pH 4 holding times and the mean pH. Results. During a 24-h fast, the pH 3 and pH 4 holding times and the mean pH were significantly higher in patients administered omeprazole (PPI; 93.2 ± 9.2%, 90.6 ± 11.1%, and 6.9 ± 0.6, respectively) than in those administered ranitidine (H2-RA; 61.0 ± 27.5%, 55.8 ± 29.1%, and 4.8 ± 1.3, respectively; P < 0.001 for all). Results were similar during feeding (PPI meal, 98.9 ± 2.6%, 98.3 ± 3.7%, and 6.9 ± 0.3; H2-RA meal, 59.8 ± 17.6%, 49.7 ± 18.0%, and 4.3 ± 0.7, respectively; P < 0.001 for all). In addition, the pH 3 and pH 4 holding times and the mean pH in the H2-RA meal group were not significantly lower than those in the H2-RA group (P = 0.999, P = 0.865, and P = 0.687, respectively). The values in the PPI and PPI meal groups were similar (P = 0.872, P = 0.777, and P > 0.999, respectively). Conclusions. Gastric acid suppression during the administration of an H2-RA or a PPI soon after the cessation of gastric bleeding was scarcely affected by feeding. It may well be that H. pylori-positive patients with bleeding gastric ulcer can resume a regular diet and return to work soon after bleeding ceases.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ozawa, T., Yoshikawa, N., Tomita, T. et al. The influence of feeding on gastric acid suppression in Helicobacter pylori-positive patients treated with a proton pump inhibitor or an H2-receptor antagonist after bleeding from a gastric ulcer. J Gastroenterol 38, 844–848 (2003). https://doi.org/10.1007/s00535-003-1159-y
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00535-003-1159-y