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Development of renal and iliac aneurysms in a child with generalized infantile myofibromatosis

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Abstract

Infantile myofibromatosis is a rare disorder characterized by the formation of tumors in the skin, soft tissues, bone, and viscera. We report the case of a 3-week-old girl who presented with severe hypertension due to generalized infantile myofibromatosis including renal involvement. The infant was treated by chemotherapy and showed progressive regression of the tumors. However, her evolution was marked by the development of aneurismal dilations of the renal and iliac arteries as observed in fibromuscular dysplasia. We discuss the possibility of a link between these two mesenchymal disorders.

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References

  1. Coffin CM (1997) Fibroblastic-myofibroblastic tumors. In: Coffin CM, Dehner LP, O’Shea PA (eds) Pediatric soft tissue tumors: a clinical, pathological, and therapeutic approach. Lippincott Williams & Wilkins, Baltimore, p 136

    Google Scholar 

  2. Schrodt BJ, Callen JP (1999) A case of congenital multiple myofibromatosis developing in an infant. Pediatrics 104:113–115

    Article  CAS  PubMed  Google Scholar 

  3. Zand DJ, Huff D, Everman D, Russell K, Saitta S, McDonald-McGinn D, Zackai EH (2004) Autosomal dominant inheritance of infantile myofibromatosis. Am J Med Genet 126A:261–266

    Article  PubMed  Google Scholar 

  4. Kasaragod AB, Lucia MS, Lum GM, Caldwell S, Stork L, Stenmark KR (1999) Solitary renal myofibromatosis: an unusual cause of infantile hypertension. Pediatrics 103:e66

    Article  CAS  PubMed  Google Scholar 

  5. Tullus K, Brennan E, Hamilton G, Lord R, McLaren CA, Marks SD, Roebuck DJ (2008) Renovascular hypertension in children. Lancet 371:1453–1463

    Article  CAS  PubMed  Google Scholar 

  6. Wright C, Corbally MT, Hayes R, McDermott MB (2004) Multifocal infantile myofibromatosis and generalized fibromuscular dysplasia in a child: evidence for a common pathologic process? Pediatr Dev Pathol 7:385–390

    Article  PubMed  Google Scholar 

  7. Coffin CM, Neilson KA, Ingels S, Frank-Gerszberg R, Dehner LP (1995) Congenital generalized myofibromatosis: a disseminated angiocentric myofibromatosis. Pediatr Pathol Lab Med 15:571–587

    CAS  PubMed  Google Scholar 

  8. Roggli VL, Kim HS, Hawkins E (1980) Congenital generalized fibromatosis with visceral involvement. A case report. Cancer 45:954–960

    Article  CAS  PubMed  Google Scholar 

  9. Slovut DP, Olin JW (2004) Fibromuscular dysplasia. N Engl J Med 350:1862–1871

    Article  CAS  PubMed  Google Scholar 

  10. Sandmann W, Schulte KM (2000) Multivisceral fibromuscular dysplasia in childhood: case report and review of the literature. Ann Vasc Surg 14:496–502

    Article  CAS  PubMed  Google Scholar 

  11. Fukuhara H, Kitayama H, Yokoyama T, Shirotani H (1996) Thromboembolic pulmonary hypertension due to disseminated fibromuscular dysplasia. Pediatr Cardiol 17:340–345

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Benoit Brasseur, Christophe F. Chantrain, Sophie Dupont, Christiane Vermylen & Bénédicte Brichard

  2. Department of Pediatrics, Cliniques Saint-Pierre, Avenue Reine Fabiola 9, 1340, Ottignies, Belgium

    Benoit Brasseur

  3. Department of Pediatric Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Nathalie Godefroid

  4. Department of Pediatric Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Thierry Sluysmans

  5. Department of Pediatric Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Christine Anslot

  6. Pediatric Radiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Renaud Menten & Philippe Clapuyt

Authors
  1. Benoit Brasseur
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  2. Christophe F. Chantrain
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  3. Nathalie Godefroid
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  4. Thierry Sluysmans
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  5. Christine Anslot
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  6. Renaud Menten
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  7. Philippe Clapuyt
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  8. Sophie Dupont
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  9. Christiane Vermylen
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  10. Bénédicte Brichard
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Corresponding author

Correspondence to Christophe F. Chantrain.

Additional information

Benoit Brasseur and Christophe F. Chantrain have contributed equally to the work.

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Brasseur, B., Chantrain, C.F., Godefroid, N. et al. Development of renal and iliac aneurysms in a child with generalized infantile myofibromatosis. Pediatr Nephrol 25, 983–986 (2010). https://doi.org/10.1007/s00467-009-1393-5

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  • DOI: https://doi.org/10.1007/s00467-009-1393-5

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