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Endoscopic submucosal resection with a ligation device for the treatment of duodenal neuroendocrine tumors

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Abstract

Background

Endoscopic submucosal resection with a ligation device (ESMR-L) is effective for rectal neuroendocrine tumors (NETs); however, its effectiveness for duodenal NETs is unclear. This study evaluated the efficacy and safety of ESMR-L for duodenal NETs.

Methods

A total of 32 consecutive patients with duodenal NETs were treated in our hospital between December 2010 and August 2015. Among these 32 patients, we retrospectively analyzed the data of all patients who underwent ESMR-L for the treatment of duodenal NETs. ESMR-L was considered for patients in whom (1) the lesion size was ≤10 mm in diameter, (2) the lesion was located within the submucosal layer, and (3) no lymph node metastasis or distant metastasis was detected.

Results

Five patients underwent ESMR-L for the treatment of duodenal NETs. The en bloc complete resection rate was 100 %. The median procedure time for ESMR-L was 15 min (range 10–30 min). In all patients, perforation during and after the operation, and intraoperative bleeding were not observed; however, one patient experienced postoperative bleeding. During follow-up, no local recurrence or distant metastasis was noted in any of the patients.

Conclusion

ESMR-L is feasible, effective, and safe for duodenal NETs measuring ≤10 mm in diameter that are confined to the submucosal layer without metastasis.

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Authors and Affiliations

  1. Department of Gastroenterology and Gastrointestinal Oncology, Endoscopy Division, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Japan

    Shozo Osera, Yasuhiro Oono, Hiroaki Ikematsu, Tomonori Yano & Kazuhiro Kaneko

Authors
  1. Shozo Osera
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  2. Yasuhiro Oono
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  3. Hiroaki Ikematsu
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  4. Tomonori Yano
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  5. Kazuhiro Kaneko
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Correspondence to Yasuhiro Oono.

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Disclosures

Shozo Osera, Yasuhiro Oono, Hiroaki Ikematsu, Tomonori Yano, and Kazuhiro Kaneko have no conflicts of interest or financial ties to disclose.

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Osera, S., Oono, Y., Ikematsu, H. et al. Endoscopic submucosal resection with a ligation device for the treatment of duodenal neuroendocrine tumors. Surg Endosc 30, 3928–3932 (2016). https://doi.org/10.1007/s00464-015-4703-y

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  • DOI: https://doi.org/10.1007/s00464-015-4703-y

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