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Comparison in prognosis after VATS lobectomy and open lobectomy for stage I lung cancer

Retrospective analysis focused on a histological subgroup

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Abstract

Background

Video-assisted thoracoscopic surgery (VATS) has become an attractive surgical procedure, but several issues remain to be resolved. Prognosis after VATS lobectomy is important to evaluate the adequacy of VATS lobectomy as a cancer operation. Interestingly, several investigators, including us, have reported that prognosis after VATS lobectomy was superior to that after open lobectomy in early non-small-cell lung cancer (NSCLC). One of the possible reasons is the low invasiveness of VATS lobectomy. But we considered that patient bias might have some influence favoring VATS lobectomy. To evaluate our hypothesis, we reviewed medical records of stage I NSCLC patients undergoing operation between 1993 and 2002. We compared and evaluated the relationship between patient characteristics and prognosis after VATS and open lobectomy. We focused particularly on histological type, classifying it into four subgroups; (1) bronchioloalveolar carcinoma (BAC), (2) mixed BAC + papillary adenocarcinoma (BAC + Pap), (3) other adenocarcinoma (Other adeno), (4) squamous cell carcinoma + others (Sq +others).

Results

A total of 165 patients underwent VATS lobectomy, and 123 patients underwent open lobectomy. The 5-year survival rate of the VATS lobectomy group was 94.5% and that of the open lobectomy group was 81.5%. Univariate Cox regression of survival revealed that male, CEA > 5, Other adeno, Sq + others, open lobectomy, and tumor size > 3 cm were significant negative prognostic variables. Multivariate Cox regression of survival revealed that histological subtype and tumor size were independent prognostic factors, but surgical procedure was not an independent prognostic factor.

Comments

Prognosis after VATS lobectomy was superior to that after open lobectomy, but patient bias influenced the prognosis in favor of VATS lobectomy, and the surgical procedure itself was not a prognostic factor.

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Authors and Affiliations

  1. Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, 160 Minamiumemoto-cho kou, Ehime, 791-0288, Japan

    S. Sawada, E. Komori & M. Yamashita

  2. Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School, Kurashiki, Japan

    M. Nakata

  3. Department of Pathology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan

    R. Nishimura & N. Teramoto

  4. Department of Medical Oncology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan

    Y. Segawa & T. Shinkai

Authors
  1. S. Sawada
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  2. E. Komori
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  3. M. Yamashita
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  4. M. Nakata
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  5. R. Nishimura
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  6. N. Teramoto
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  7. Y. Segawa
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  8. T. Shinkai
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Correspondence to S. Sawada.

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Sawada, S., Komori, E., Yamashita, M. et al. Comparison in prognosis after VATS lobectomy and open lobectomy for stage I lung cancer. Surg Endosc 21, 1607–1611 (2007). https://doi.org/10.1007/s00464-007-9200-5

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  • DOI: https://doi.org/10.1007/s00464-007-9200-5

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