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Systematic evaluation of cancer risk associated with DNMT3B polymorphisms

  • Original Article – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The aim of our study is to provide a precise quantification for the association between DNA methyltransferase 3B (DNMT3B) variations (rs2424913 C/T, rs1569686 G/T, rs6087990 T/C and rs2424908 T/C) and the risk of cancer.

Methods

We performed a systematic literature review and assessed the methodological quality of included case–control designed studies based on Newcastle–Ottawa Scale. Pooled odds ratios (ORs) and corresponding 95 % confidence intervals (95 % CIs) were calculated to assess the strengths of the associations.

Results

We identified 34 studies for pooled analyses. Overall, the results demonstrated that rs2424913 polymorphism was significantly associated with negative cancer risk in the African population (CT vs TT: OR 0.10, 95 % CI 0.02–0.63, P = 0.01; CT+CC vs TT: OR 0.14, 95 % CI 0.03–0.76, P = 0.02), and the rs1569686 polymorphism was significantly associated with a subtly decreased cancer risk (GT vs TT: OR 0.80, 95 % CI 0.72–0.90, P < 0.01; GT+GG vs TT: OR 0.84, 95 % CI 0.76–0.94, P < 0.01), particularly in the Asian population (GT vs TT: OR 0.79, 95 % CI 0.66–0.96, P < 0.01) and in colorectal cancer subgroup (G vs T: OR 0.69, 95 % CI 0.54–0.88, P < 0.01). In addition, the rs6087990 polymorphism was associated with decreased risk in Asian population (T vs C: OR 0.77, 95 % CI 0.62–0.96, P = 0.02). Similarly, the rs2424908 polymorphism was observed as a protective factor for cancer in the Asian population (CT+CC vs TT: OR 0.79, 95 % CI 0.66–0.95, P = 0.01).

Conclusions

DNMT3B polymorphisms might be associated with decreased cancer risk especially in the Asian population and for colorectal cancer. Further multicentric studies are still needed to confirm the results.

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Acknowledgments

This research was supported by People’s Republic of China National Natural Science Foundation of China (No. 81202278), and Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 2010HASTIT027), and Excellent Youth Foundation of He’nan Scientific Committee (No. 124100510007).

Conflict of interest

The authors declare no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Hospital Infection Management, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China

    Fujiao Duan, Xia Zhao & Xiaoqin Zhang

  2. College of Professional Study, Northeastern University, Boston, MA, USA

    Shuli Cui

  3. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China

    Chunhua Song & Liping Dai

  4. Henan Key Laboratory of Tumor Epidemiology, Zhengzhou, Henan, China

    Chunhua Song & Liping Dai

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  1. Fujiao Duan
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  2. Shuli Cui
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  3. Chunhua Song
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  4. Liping Dai
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  5. Xia Zhao
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  6. Xiaoqin Zhang
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Correspondence to Fujiao Duan.

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Duan, F., Cui, S., Song, C. et al. Systematic evaluation of cancer risk associated with DNMT3B polymorphisms. J Cancer Res Clin Oncol 141, 1205–1220 (2015). https://doi.org/10.1007/s00432-014-1894-x

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