Abstract
There are several entities that can present with multiple nodular lesions within the peritoneal cavity, such as “disseminated peritoneal leiomyomatosis,” “peritoneal fibrosis,” “calcifying fibrous pseudotumor,” and the recently described lesion of “reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery.” Here we present one such lesion in a 28-year-old woman with a history of dysmenorrhea and ergotamine use for migraine attacks. Intraoperative exploration of our patient disclosed numerous nodules located throughout the pelvic and abdominal peritoneum. Histopathologically, these lesions were fibrocollagenous nodules composed of sparse wavy spindle cells within hyalinized “keloid-like” collagen surrounded by an inflammatory infiltrate. Some of the nodules were associated with small foci of endometriosis. We believe this lesion is best described by the term “reactive nodular fibrous pseudotumor” and that endometriosis and the use of ergotamine derivatives may be contributing factors.
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Chatelain D, Manaouil D, Levy P, Joly JP, Sevestre H, Regimbeau JM (2004) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery. Am J Surg Pathol 28:416
Clement PB, Young RH, Hanna W, Scully RE (1994) Sclerosing peritonitis associated with luteinized thecomas of the ovary. A clinicopathological analysis of six cases. Am J Surg Pathol 18:1–13
Clement PB (1995) Reactive tumor-like lesions of the peritoneum. Am J Clin Pathol 103:673–676
Clement PB (2002) Diseases of the peritoneum. In: Kurman RJ (ed) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York, pp 731–732
Daum O, Vanecek T, Sima R, Curik R, Zamecnik M, Yamanaka S, Mukensnabl P, Benes Z, Michal M (2004) Reactive nodular fibrous pseudotumors of the gastrointestinal tract: a report of 8 cases. Int J Surg Pathol 12:365–374
Itoga T, Matsumoto T, Takeuchi H, Yamasaki S, Sasahara N, Hoshi T, Kinoshita K (2003) Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis. Pathol Int 53:371–375
Nascimento AF, Ruiz R, Hornick JL, Fletcher CD (2002) Calcifying fibrous “pseudotumor”: clinicopathologic study of 15 cases and analysis of its relationship to inflammatory myofibroblastic tumor. Int J Surg Pathol 10:189–196
Robert M, Derbaudrenghien JP, Blampain JP, Lamy F, Meyer P (1984) Fibrotic processes associated with long-term ergotamine therapy. N Engl J Med 311:601–602
Yantiss RK, Nielsen GP, Lauwers GY, Rosenberg AE (2003) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery: a clinicopathologic study of five cases. Am J Surg Pathol 27:532–540
Zaloudek C, Hendrickson MR (2002) Mesenchymal tumors of the uterus. In: Kurman RJ (ed) Blaustein's pathology of the female genital tract. Springer, Berlin Heidelberg New York, pp 577–578
Zardawi IM, Catterall N, Cox SA (2004) Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery. Am J Surg Pathol 28:276–277
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Saglam, E.A., Usubütün, A., Kart, C. et al. Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch 447, 879–882 (2005). https://doi.org/10.1007/s00428-005-0027-y
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DOI: https://doi.org/10.1007/s00428-005-0027-y