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Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma

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Abstract

Introduction

Malignant brain tumors have been reported to occur after childhood irradiation more frequently than in the nonirradiated population.

Discussion

In this study, we report the case of a 15-year-old boy treated for medulloblastoma with surgery and craniospinal radiotherapy, who developed a meningioma 18 years after initial treatment and subsequently an anaplastic astrocytoma 23 years after primary treatment. The meningioma was resected without complications. The patient is currently alive but with recurrent astrocytoma after a complete remission on temozolomide monotherapy. Second malignancies are a rare, potentially devastating risk in cancer survivors, with risk continuing lifelong.

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Conflict of interest

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Radiation Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, St. Louis, MO, 63110, USA

    Andrew J. Hope, David B. Mansur & Joseph R. Simpson

  2. Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St. Louis, MO, 63110, USA

    Pang-Hsien Tu

Authors
  1. Andrew J. Hope
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  2. David B. Mansur
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  3. Pang-Hsien Tu
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  4. Joseph R. Simpson
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Corresponding author

Correspondence to Joseph R. Simpson.

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Hope, A.J., Mansur, D.B., Tu, PH. et al. Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. Childs Nerv Syst 22, 1201–1207 (2006). https://doi.org/10.1007/s00381-006-0062-2

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  • DOI: https://doi.org/10.1007/s00381-006-0062-2

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