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Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas

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Abstract

Objectives

The purposes of this MR-based study were to calculate q-space imaging (QSI)–derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour cell count (TCC) and MIB-1 labelling index (LI).

Methods

MRI, including QSI and conventional diffusion-weighted imaging (DWI), was performed in 44 meningioma patients (52 lesions). ADC and MDP maps were acquired from post-processing of the data. Quantitative analyses of these maps were performed by applying regions of interest. Pearson correlation coefficients were calculated for ADC and MDP in all lesions and for ADC and TCC, MDP and TCC, ADC and MIB-1 LI, and MDP and MIB-1 LI in 17 patients who underwent subsequent surgery.

Results

ADC and MDP values were found to have a strong correlation: r = 0.78 (P = <0.0001). Both ADC and MDP values had a significant negative association with TCC: r = –0.53 (p = 0.02) and –0.48 (P = 0.04), respectively. MIB-1 LI was not, however, found to have a significant association with these diffusion parameters.

Conclusion

In meningiomas, both ADC and MDP may be representative of cell density.

Key Points

• Diffusion-weighted MRI offers possibilities to assess the aggressiveness of meningiomas.

• The q-space imaging-derived mean displacement correlates strongly with apparent diffusion coefficients.

• Both diffusion parameters showed a strong negative association with tumour cell counts.

• Derived mean displacement may help assess the aggressiveness of meningiomas preoperatively.

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Abbreviations

QSI:

q-Space imaging

MDP:

Mean displacement

DWI:

Diffusion-weighted imaging

ADC:

Apparent diffusion coefficient

MIB-1 LI:

MIB-1 labelling index

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Acknowledgments

We acknowledge the invaluable contributions of Mr. Hiroshi Kumagai and Mr. Satoshi Ikenaga, Department of Radiology, University of Yamanashi, in carrying out all the imaging for this study.

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Authors and Affiliations

  1. Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi, 409-3898, Japan

    Zareen Fatima, Utaroh Motosugi, Keiichi Ishigame & Tsutomu Araki

  2. Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi, 409-3898, Japan

    Ahmed Bilal Waqar

  3. Department of Radiology, School of Medicine, Juntendo University, Tokyo, 113-8421, Japan

    Masaaki Hori

  4. Department of Pathology, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi, 409-3898, Japan

    Naoki Oishi & Ryohei Katoh

  5. Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, 116-8551, Japan

    Toshiyuki Onodera & Kazuo Yagi

Authors
  1. Zareen Fatima
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  2. Utaroh Motosugi
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  3. Ahmed Bilal Waqar
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  4. Masaaki Hori
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  5. Keiichi Ishigame
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  7. Toshiyuki Onodera
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  8. Kazuo Yagi
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  9. Ryohei Katoh
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  10. Tsutomu Araki
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Correspondence to Keiichi Ishigame.

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Fatima, Z., Motosugi, U., Waqar, A.B. et al. Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas. Eur Radiol 23, 2258–2263 (2013). https://doi.org/10.1007/s00330-013-2823-0

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  • DOI: https://doi.org/10.1007/s00330-013-2823-0

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