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Antinuclear antibody-negative systemic lupus erythematosus in a case with pregnancy

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Abstract

We described a 30-year-old pregnant woman developing antinuclear antibodies (ANA)-negative systemic lupus erythematosus (SLE) accompanied with arthritis, malar rash, lymphopenia, autoimmune hemolytic anemia, pericardial and pleural effusion, proteinuria and seizures. All serum autoantibodies except anti-Ro antibody were negative. An artificially induced abortion was performed to prevent SLE deterioration. Steroid and cyclophosphamide therapy were effective for this patient. During the 2-year follow-up period, her ANA and other SLE-related autoantibodies in serum remained negative. This case suggests that ANA may not be required in the pathogenesis of SLE, even in the case with pregnancy, and ANA-negative SLE may also have a dangerous clinical course.

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Authors and Affiliations

  1. Department of Rheumatology and Immunology, West China Hospital of Sichuan University, 610041, Chengdu, Sichuan, China

    Qibing Xie, Yi Liu, Nanping Yang & Geng Yin

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  1. Qibing Xie
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  2. Yi Liu
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  3. Nanping Yang
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  4. Geng Yin
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Correspondence to Geng Yin.

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Xie, Q., Liu, Y., Yang, N. et al. Antinuclear antibody-negative systemic lupus erythematosus in a case with pregnancy. Rheumatol Int 32, 3273–3276 (2012). https://doi.org/10.1007/s00296-010-1487-1

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  • DOI: https://doi.org/10.1007/s00296-010-1487-1

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