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Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome): a report of two cases and review of the literature

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Abstract

We report two cases of paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE) associated with prostatic adenocarcinoma. One of the patients was positive for Helicobacter pylori and the other had secondary bone metastases. In the latter, the clinical picture of RS3PE developed after surgical intervention for the primary lesion. On physical examination, while the hands and feet were swollen in the first patient, pitting edema was present only at the feet of the other. All joints of the affected hands and feet were painful. Serological tests including rheumatoid factor, antinuclear antibody, and human leukocyte antigen B27 were all negative. Response to low-dose corticosteroid treatment was delayed in the first patient, but the symptoms were relieved better in the second one.

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Authors and Affiliations

  1. Department of Rheumatology, Suleyman Demirel University Medical School, Isparta, Turkey

    S. Ercan Tunc

  2. Department of Internal Medicine, Suleyman Demirel University Medical School, Isparta, Turkey

    Cagatay Arslan

  3. Department of Physical Medicine and Rehabilitation, Suleyman Demirel University Medical School, Isparta, Turkey

    Naime Bayram Ayvacioglu & Selami Akkus

  4. Department of Immunology, Suleyman Demirel University Medical School, Isparta, Turkey

    Mehmet Sahin

  5. Department of Orthopedics, Suleyman Demirel University Medical School, Isparta, Turkey

    Huseyin Yorgancigil

  6. Istanbul Cad. No:33/8, 32200, Isparta, Turkey

    S. Ercan Tunc

Authors
  1. S. Ercan Tunc
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  2. Cagatay Arslan
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  3. Naime Bayram Ayvacioglu
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  4. Mehmet Sahin
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  5. Selami Akkus
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  6. Huseyin Yorgancigil
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Correspondence to S. Ercan Tunc.

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Tunc, S.E., Arslan, C., Ayvacioglu, N.B. et al. Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome): a report of two cases and review of the literature. Rheumatol Int 24, 234–237 (2004). https://doi.org/10.1007/s00296-003-0395-z

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  • DOI: https://doi.org/10.1007/s00296-003-0395-z

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