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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners

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Abstract

LIGHT and herpes virus entry mediator (HVEM) comprise a ligand–receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin β receptor, and HVEM can act as a ligand for immunoglobulin family molecules, including B- and T-lymphocyte attenuator, which suppresses immune responses. Complexity in this pivotal system arises from several factors, including the non-monogamous pairing of ligands and receptors, and reverse signaling or the ability of some ligands to serve as receptors. As a result, recognition events in this fascinating network of interacting molecules can have pro- or anti-inflammatory consequences. Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation.

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Acknowledgments

This work was supported by grants from the National Institutes of Health AI61516 to M.K. and AI06789001 to C.F.W.; by a NIDDK postdoctoral fellowship (DK082249) to J-W. S; by a Research Fellowship Award from the Crohn’s & Colitis Foundation of America to M.W.S. and by the University of California, San Diego, Digestive Diseases Research Development Center (DK 080506). The authors have no conflicting financial interests. This is manuscript number 1143 from the La Jolla Institute for Allergy and Immunology.

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  1. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA

    Marcos W. Steinberg, Jr-Wen Shui & Mitchell Kronenberg

  2. Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA

    Carl F. Ware

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  1. Marcos W. Steinberg
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Correspondence to Mitchell Kronenberg.

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Steinberg, M.W., Shui, JW., Ware, C.F. et al. Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners. Semin Immunopathol 31, 207–221 (2009). https://doi.org/10.1007/s00281-009-0157-4

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