References
Kawajiri C, Tanaka H, Hashimoto S et al (2014) Successful treatment of Philadelphia chromosome-positive mixed phenotype acute leukemia by appropriate alternation of second-generation tryrosine kinase inhibitors according to BCR-ABL1 mutation status. Int J Hematol 99:513–518
Swerdlow SH, Campo E, Harris NL et al (2008) WHO classification of tumors of haematopoietic and lymphoid tissues. International Agency for Research on Cancer, France
Matutes E, Pickl WF, Van't Veer M et al (2011) Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Blood 117:3163–3171
Manola KN (2013) Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview. Br J Haematol 163:24–39
Allen A, Gill K, Hoehn D et al (2014) C-myc protein expression in B-cell acute lymphoblastic leukemia, prognostic significance? Leuk Res 38:1061–1066
Cook JR, Goldman B, Tubbs RR et al (2014) Clinical significance of MYC expression and/or “high-grade” morphology in non-Burkitt, diffuse aggressive B-cell lymphomas: a SWOG S9704 correlative study. Am J Surg Pathol 38:494–501
Leibundgut EO, Jotterand M, Rigamonti V et al (1999) A novel BCR-ABL transcript e2a2 in a chronic myelogenous leukaemia patient with a duplicated Ph-chromosome and monosomy 7. Br J Haematol 106:1041–1044
Hamaguchi H, Nakamura Y, Nagata K et al (1993) Philadelphia-chromosome-positive, monosomy 7 biphenotypic acute mixed lineage leukemia in adults: a pluripotent stem cell disorder. Leukemia 7:1752–1758
Futaki M, Ito T, Inokuchi K et al (1989) Philadelphia-positive acute mixed leukemia with monosomy 7. Rinsho Ketsueki 30:1997–2001
Soligo D, Polli N, Cattoretti G et al (1986) Biphenotypic Philadelphia positive, monosomy seven acute leukaemia: ultrastructural immunocytochemical study. J Submicrosc Cytol 18:433–440
Béné MC, Porwit A (2012) Acute leukemias of ambiguous lineage. Semin Diagn Pathol 29:12–18
Conflicts of interest
The authors declare that they have no competing interests.
Financial support
None.
Author contributions
Drs. Zhaodong Xu, Ruth Padmore, and Luke Shier were responsible for the flow immunophenotyping and immunohistochemistry analyses that led to the diagnosis of mixed phenotype acute leukemia with C-MYC over-expression. Dr. Melanie Beaulieu Bergeron was responsible for the standard chromosome analysis and FISH testing. Dr. Xu was the main author of the manuscript, in collaboration with Dr Beaulieu Bergeron.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Xu, Z., Padmore, R., Shier, L. et al. A rare case of acute leukemia of ambiguous lineage overexpressing C-MYC with monosomy 7 and Philadelphia chromosome. Ann Hematol 94, 1761–1763 (2015). https://doi.org/10.1007/s00277-015-2443-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-015-2443-7