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Electrocatalytic oxidation of NADH at single-wall carbon-nanotube-paste electrodes: kinetic considerations for use of a redox mediator in solution and dissolved in the paste

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Abstract

Cyclic voltammetry has been successfully used to study the oxidation of nicotinamide adenine dinucleotide (NADH) at single-wall carbon-nanotube-paste (CNTP) electrodes modified with p-methylaminophenolsulfate (p-MAP) and 3,4-dihydroxybenzaldehyde (3,4-DHB). Diffusion-like behaviour was observed for p-MAP-modified electrodes, and a diffusion coefficient of 2.4×10−6 cm2 s−1 was calculated for p-MAP in the paste. The behaviour of 3,4-DHB-modified CNTP electrodes was typical of that of surface-confined mediators. p-MAP electrocatalytic activity was first checked in solution, and a rate constant of 9.2 mol−1 L s−1 was obtained for the reaction between NADH and the mediator. The p-MAP-modified electrode did not have significant electrocatalytic activity for electro-oxidation of NADH, probably because of the formation of a complex between NADH and the confined mediator. In contrast, the 3,4-DHB-modified electrode had very good NADH electrocatalytic activity, with a heterogeneous rate constant of approximately 20×102 mol−1 L s−1.

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Acknowledgements

The financial support of Italian Ministry of Education University and Scientific Research (PRIN 2002) is acknowledged.

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Authors and Affiliations

  1. Dipartimento di Scienze Chimiche, Università di Padova, Via Marzolo 1, 35131, Padova, Italy

    Riccarda Antiochia, Irma Lavagnini & Franco Magno

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  1. Riccarda Antiochia
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  2. Irma Lavagnini
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  3. Franco Magno
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Correspondence to Riccarda Antiochia.

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Antiochia, R., Lavagnini, I. & Magno, F. Electrocatalytic oxidation of NADH at single-wall carbon-nanotube-paste electrodes: kinetic considerations for use of a redox mediator in solution and dissolved in the paste. Anal Bioanal Chem 381, 1355–1361 (2005). https://doi.org/10.1007/s00216-005-3079-6

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