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Determinants of health-related quality of life in women with vertebral fractures

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Abstract

Health-related quality of life (HRQL) is an important consideration in the management of patients with vertebral fractures. The purpose of this study was to examine patient-related factors that contribute to HRQL after vertebral fractures, including co-morbidities, medications, fracture history, family disease history, demographics, exercise, education and living environment. A total of 1,129 post-menopausal women (mean age 67.2, SD 11.9 years) was studied from the Canadian Database of Osteoporosis and Osteopenia (CANDOO). HRQL was measured using the mini-osteoporosis quality of life questionnaire (mini-OQLQ). Separate multivariable linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] were performed for each of the five mini-OQLQ domains: symptoms, physical functioning, emotional functioning, activities of daily living and leisure domains. A strong positive association was found between HRQL and post-secondary education, a family history of osteoporosis, working and thiazide therapy. Exercise improved HRQL; however, several hours a week were required to be meaningful. Living in long-term care had the most marked negative effect on HRQL. Smoking, past surgery of the hip or spine, sedatives, anticonvulsants, atherosclerotic disease and hypertension were also associated with a substantially decreased HRQL across several domains. Calcium channel-blockers, chemotherapy, corticosteroids, diabetes, migraines, the number of non-vertebral fractures and falls had a negative impact on selected domains. We demonstrated that several modifiable factors influence HRQL in patients with vertebral fractures, and physicians should be aware of these and other markers of reduced HRQL to enhance patient care.

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Article Open access 01 July 2023

Enisa Shevroja, Jean-Yves Reginster, … Nicholas C. Harvey

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Authors and Affiliations

  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Alexandra Papaioannou, Courtney C. Kennedy, George Ioannidis, Anjali Pathak, Annie Petrie & Jonathan D. Adachi

  2. Centre Hospitalier de l’Universite Laval, Ste-Foy, Quebec, Canada

    Jacques P. Brown

  3. Department of Medicine, University of Calgary, Calgary, Alberta, Canada

    David A. Hanley

  4. University of Toronto, Toronto, Ontario, Canada

    Robert G. Josse & Timothy M. Murray

  5. Department of Clinical Epidemiology and Biostatistics, St Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada

    Rolf J. Sebaldt & Charles H. Goldsmith

  6. Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Wojciech P. Olszynski

  7. Division of Bone Metabolism, The Montreal General Hospital, Montreal, Quebec, Canada

    Alan Tenenhouse

  8. Department of Medicine, Hamilton Health Sciences, Chedoke Site Sanatorium Road Building 74 Room 5, Hamilton, Ontario, L9C 7N4, Canada

    Alexandra Papaioannou

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  1. Alexandra Papaioannou
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  2. Courtney C. Kennedy
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  3. George Ioannidis
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  11. Timothy M. Murray
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Correspondence to Alexandra Papaioannou.

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Papaioannou, A., Kennedy, C.C., Ioannidis, G. et al. Determinants of health-related quality of life in women with vertebral fractures. Osteoporos Int 17, 355–363 (2006). https://doi.org/10.1007/s00198-005-2020-3

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  • DOI: https://doi.org/10.1007/s00198-005-2020-3

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