The Pathogenic Enteric Protozoa:

1. Front Matter

   Pages i-xiii

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2. Epidemiology

   1. Epidemiology and Zoonotic Potential of Giardia Infections

      • R C Andrew Thompson

      Pages 1-12

   2. Entamoeba Histolytica and Entamoeba Dispar, the Non-Identical Twins

      • C. Graham Clark

      Pages 15-26

   3. Epidemiology and Strain Variation of Cryptosporidium

      • R. M. Chalmers, D. P. Casemore

      Pages 27-42

   4. Cyclospora Cayetanensis: An Emergent and Still Perplexing Coccidian Parasite

      • Charles R. Sterling, Ynes R. Ortega

      Pages 43-57

3. Host parasite interactions

   1. Antigenic Variation of the VSP Genes of Giardia Lamblia

      • Rodney D. Adam, Theodore E. Nash

      Pages 59-73

   2. Pathogenisis and Immunity to Entamoeba Histolytica

      • Jessica L. Tarleton, William A. Petri Jr.

      Pages 75-89

   3. Innate and T Cell-Mediated Immune Responses in Cryptosporidiosis

      • Carol R. Wyatt, Vincent McDonald

      Pages 91-101

4. Treatment and Control

   1. Rationale Approaches to Treating Cryptosporidium, Cyclospora, Giardia and Entamoeba

      • Jan R. Mead, Pablo Okhuysen

      Pages 103-115

   2. Inactivation and Removal of Enteric Protozoa in Water

      • F. W. Schaefer III, M. M. Marshall, J. L. Clancy

      Pages 117-127

   3. Monitoring of Giardia and Cryptosporidium in Water in the UK and US

      • J. L. Clancy, P. R. Hunter

      Pages 129-139

5. Genomics

   1. Entamoeba Histolytica Genome

      • J. J. McCoy, B. J. Mann

      Pages 141-152

   2. Cryptosproridium Parvum Genomics: Impact on Research and Control

      • G. Zhu, M. S. Abrahamsen

      Pages 153-163

6. Back Matter

   Pages 165-169

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Giardia duodenalis (=G. lamblia), Entamoeba histolytica, Cryptosporidium parvum and Cyclospora cayetanensis are more than just a mouthful for most who might encounter them. These protozoan parasitic agents contribute significantly to the staggering caseload of diarrheal disease morbidity encountered in developing world nations. Compounding the issue of their mere presence is the fact that standard ova and parasite exams frequently do not detect these infections. Detectable stages may be shed intermittently or require specialized staining procedures. Added to this is the often large number of asymptomatic carriers who serve as reservoirs for infecting others. These parasites are also not strangers to more developed nations, having responsibility for both small and large-scale disease outbreaks. In such settings they may be even more difficult to detect simply because they are frequently overlooked in the grand scheme of disease causing possibilities. They share common features; all are Protozoa, all possess trophic stages that inhabit the gastrointestinal tract, all have the ability to produce disease and in some instances death, and all produce environmentally stable cysts or oocysts, which ensure their transmissibility. In other ways, these organisms are profoundly different. Giardia is a flagellate that inhabits the gut lumen in close association with enterocytes. Entamoeba is an amoeba that preferentially inhabits the mucosal region of the gut lumen, but which may, under certain circumstances, become invasive. Cryptosporidium and Cyclospora are obligate intracellular coccidians, each taking up a unique niche within their respective host enterocytes.

• antigen
• epidemiology
• gastrointestinal tract
• genomics
• infection
• parasite
• parasites
• pathogenesis
• protozoa

• University of Arizona, Tucson

  Charles R. Sterling, Rodney D. Adam

Charles R. Sterling is a Professor in the Department of Veterinary Science and Microbiology at the University of Arizona, Tucson, Arizona. Rodney D. Adam is a Professor in the Department of Microbiology and Immunology at the University Of Arizona Health Science Center, Tucson, Arizona.

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