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Bone disease in anorexia nervosa

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Abstract

Anorexia nervosa is a serious psychiatric disorder accompanied by high morbidity and mortality. It is characterized by emaciation due to self-starvation and displays a unique hormonal profile. Alterations in gonadal axis, growth hormone resistance with low insulin-like growth factor I levels, hypercortisolemia and low triiodothyronine levels are almost universally present and constitute an adaptive response to malnutrition. Bone metabolism is likewise affected resulting in low bone mineral density, reduced bone accrual and increased fracture risk. skeletal deficits often persist even after recovery from the disease with serious implications for future skeletal health. The pathogenetic mechanisms underlying bone disease are quite complicated and treatment is a particularly challenging task.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Hippokrateion General Hospital, Athens, Greece

    Anastasia D. Dede MD

  2. Hellenic Osteoporosis Foundation, University of Athens, KAT Hospital, Athens, Greece

    George P. Lyritis

  3. Laboratory for Research of Musculoskeletal System “Theodoros Garofalidis”, University of Athens, KAT Hospital, Athens, Greece

    Symeon Tournis

  4. 1 M. Katraki Str., Zografos, 15771, Athens, Greece

    Anastasia D. Dede MD

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Dede, A.D., Lyritis, G.P. & Tournis, S. Bone disease in anorexia nervosa. Hormones 13, 38–56 (2014). https://doi.org/10.1007/BF03401319

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