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Lack of stimulatory effect of 1,25(OH)2 vitamin D3 on ß-endorphin and cortisol secretion

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Abstract

The aim of the work was to investigate the effect of 1,25 (OH)2 vitamin D3 on ß-endorphin and Cortisol secretion in vivo. ß-Endorphin, Cortisol, calcium and phosphate in blood were measured in ten healthy unstressed volunteers before and after 4-day oral administration of 1,25 (OH)2 vitamin D3 in doses of 3 µg/d. The biological effectiveness of the treatment was proved by a significant increase of calcemia as compared with control values (2.71±0.03 vs 2.57±0.02 mmol/l, mean±SE, p<0.01) and phosphatemia (1.18±0.06 vs 0.89±0.01 mmol/l, p<0.01). ß-Endorphin after treatment was 39.1 ±9.2 (vs 42.7±7.6) ng/l and Cortisol 369±35 (vs 377±31) nmol/l. In conclusion, in spite of the good compliance of the treatment, 1,25 (OH)2-vitamin D3 stimulates neither ß-endorphin nor Cortisol secretion in healthy subjects.

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Authors and Affiliations

  1. Institute of Endocrinology, Národní 8, 116 94, Prague 1, Czech Republic

    I. Z̆ofková M.D., PhD, DSc & R. L. Kancheva

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  1. I. Z̆ofková M.D., PhD, DSc
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  2. R. L. Kancheva
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This study was supported by Research Grant No 0004-2 from the Ministry of Health, Czech Republic.

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Z̆ofková, I., Kancheva, R.L. Lack of stimulatory effect of 1,25(OH)2 vitamin D3 on ß-endorphin and cortisol secretion. J Endocrinol Invest 17, 693–695 (1994). https://doi.org/10.1007/BF03347759

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  • DOI: https://doi.org/10.1007/BF03347759

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