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Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty

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Abstract

Background: Allopregnanolone, a neuroactive steroid mainly secreted by adrenals and gonads, is a hormone that seems to play a role in precocious puberty, as demonstrated by its high baseline levels found in girls with central precocious puberty (CPP). Allopregnanolone concentrations significantly increase after GnRH and ACTH stimulation test suggesting both its ovarian and adrenal production. Aim: Aim of this study was to evaluate allopregnanolone concentrations after GnRH and GnRH agonist analog stimulation test in girls with CPP to better establish its secretion source. Subjects and methods: Gonadotropins and steroid hormones were evaluated in different days after GnRH and triptorelin stimulation test in 15 CPP girls. Results: After GnRH stimulation, LH, FSH, and allopregnanolone concentrations significantly increased (p<0.05). After triptorelin administration LH, FSH, estradiol and DHEAS levels significantly increased (p<0.05), while allopregnanolone concentrations significantly decreased (1.08±0.24 vs 0.87±0.28 nmol/l; p=0.003). Conclusions: The different response of allopregnanolone to GnRH and GnRH agonist analog might reflect the agonist and antagonist action exerted by these secretagogues. Our data suggest the prevalent gonadal allopregnanolone production in CPP subjects and the usefulness of its measurement in the diagnosis of CPP.

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Authors and Affiliations

  1. Department of Pediatrics, University of Modena and Reggio Emilia, Modena, Italy

    B. Predieri MD & L. Iughetti

  2. Department of Obstetrics and Gynecology, University of Siena, Siena, Italy

    S. Luisi & F. Petraglia

  3. Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy

    E. Casarosa

  4. Department of Pediatrics, University of Perugia, Perugia, Italy

    E. Farinelli

  5. Department of Pediatrics, University of Verona, Verona, Italy

    F. Antoniazzi

  6. Department of Pediatrics, University of Messina, Messina, Italy

    M. Wasniewska

  7. Department of Pediatrics, University of Parma, Parma, Italy

    S. Bernasconi

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  1. B. Predieri MD
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  2. S. Luisi
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  3. E. Casarosa
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  9. L. Iughetti
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Italian Society of Pediatric Endocrinology and Diabetology - Study Group of Puberty

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Correspondence to B. Predieri MD.

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Predieri, B., Luisi, S., Casarosa, E. et al. Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty. J Endocrinol Invest 34, 38–44 (2011). https://doi.org/10.1007/BF03346693

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