Abstract
Preoperative levels of serum soluble interleukin-2 receptor (IL-2R) were examined in 37 patients with breast cancer. We investigated the correlations of serum soluble IL-2R levels with various factors such as stage grouping, lymph node metastasis, distant metastasis, tumor size, histopathological type, estrogen receptor (ER), progesterone receptor (PgR) and CA 153. Serum soluble IL-2R levels were measured with an enzyme-linked immunosorbent assay.
Levels of serum soluble IL-2R in the patients with stage III and IV breast cancer were significantly higher than those in the normal controls, and patients with stage I and II breast cancer. Preoperative levels of serum soluble IL-2R in patients with T3 and T4 were also significantly higher than those in patients with T1 and T2. Serum levels of IL-2R in patients with distant metastasis were also significantly higher than those in patients without distant metastasis. Moreover, serum levels of soluble IL-2R in patients with higher CA 15-3 were significantly higher than those in patients with normal CA 15-3 levels.
We conclude that preoperative serum soluble IL-2R levels in patients with breast cancer may be a valuable parameter, especially in evaluating whether they have distant metastasis or not.
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Abbreviations
- IL-2R:
-
Interleukin-2 receptor
- ER:
-
Estrogen receptor
- PgR:
-
Progesterone receptor
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Murakami, S., Hirayama, R., Satomi, A. et al. Serum soluble interleukin 2 receptor levels in patients with breast cancer. Breast Cancer 4, 25–28 (1997). https://doi.org/10.1007/BF02967051
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DOI: https://doi.org/10.1007/BF02967051