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Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

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Abstract

A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.

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Authors and Affiliations

  1. Bluestone Laboratory, Division of Neuropathology, Department of Pathology, Montefiore Medical Center, 111 East 210th Street, 10467, Bronx, NY

    Hiroshi Nishioka & Asao Hirano

  2. Department of Pathology, St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

    Sylvia L. Asa

Authors
  1. Hiroshi Nishioka
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  2. Asao Hirano
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  3. Sylvia L. Asa
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Nishioka, H., Hirano, A. & Asa, S.L. Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?. Endocr Pathol 3, 47–51 (1992). https://doi.org/10.1007/BF02921343

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