Abstract
The effects of stimulating locus coeruleus (LC) on neuronal activity of cerebellar fastigii nucleus (FN) was investigated. Stimulation of LC elicited inhibitory, excitatory and biphasic (inhibition-excitation) responses from FN cells. The majority of responsive cells showed an inhibitory response with a latency of less than 10 ms. Injection of a adrenoreceptor antagonists phentolamine (iV) could block the inhibitory response of FN cells to the LC stimulation, but propranolol (IV), a β adrenoreceptor antagonist, could not. These results suggest that LC-cerebellar noradrenergic afferent fibers may be involved in the cerebellar sensorimotor integration process by exerting their modulatory action on the cerebellar nuclear cells’ activities.
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Tao, W., Jianjun, W., Hong, C. et al. Modulation of neuronal activity of cerebellar fastigial nucleus by locus coeruleus stimulation in the rat. Chin. Sci. Bull. 43, 940–944 (1998). https://doi.org/10.1007/BF02884618
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DOI: https://doi.org/10.1007/BF02884618