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Cognitive impairment in schizophrenia spectrum personality

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Current Psychosis & Therapeutics Reports

Abstract

Among the most prevalent and debilitating features of disorders on the schizophrenia spectrum are cognitive impairments. However, the pattern and severity of these impairments differ among individuals and across illnesses. The extent to which cognitive dysfunction occurs throughout the spectrum informs us about the pathophysiology of schizophrenia, the potential for treatment, and implications for the course of the illness. This article reviews the most recent findings on cognition in schizophrenia spectrum disorders, focusing on schizotypal personality disorder. Implications and directions for future research are offered.

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References and Recommended Reading

  1. Cornblatt BA, Erlenmeyer-Kimling L:Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity.J Abnorm Psychol 1985,94:470–486.

    Article  PubMed  CAS  Google Scholar 

  2. Davidson M, Reichenberg A, Rabinowitz J,et al.:Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents.Am J Psychiatry 1999,156:1328–1335.

    PubMed  CAS  Google Scholar 

  3. Bilder RM, Goldman RS, Robinson D,et al.:Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates.Am J Psychiatry 2000,157:549–559.

    Article  PubMed  CAS  Google Scholar 

  4. Heaton RK, Gladsjo JA, Palmer BW,et al.:Stability and course of neuropsychological deficits in schizophrenia.Arch Gen Psychiatry 2001,58:24–32.

    Article  PubMed  CAS  Google Scholar 

  5. Friedman H, Harvey PD, Coleman T,et al.:Six-year follow-up study of cognitive and functional status across the lifespan in schizophrenia: a comparison with Alzheimer’s disease and normal aging.Am J Psychiatry 2001,158:1441–1448.

    Article  PubMed  CAS  Google Scholar 

  6. Bowie CR, Reichenberg A, Patterson TL,et al. Determinants of real world functional performance in schizophrenia: correlations with cognition, functional capacity, and symptoms.Am J Psychiatry, In press.

  7. Siever LJ, Davis KL:The pathophysiology of schizophrenia disorders: perspectives from the spectrum.Am J Psychiatry 2004,161:398–413.

    Article  PubMed  Google Scholar 

  8. Saykin AJ, Gur RC, Cur RE,et al.:Neuropsychological function in schizophrenia. Selective impairment in memory and learning.Arch Gen Psychiatry 48:618–624.

  9. Cadenhead KS, Geyer MA, Braff DL:Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder.Am J Psychiatry 1993,150:1862–1867.

    PubMed  CAS  Google Scholar 

  10. Cadenhead KS, Swerdlow NR, Shafer KM,et al.:Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits.Am J Psychiatry 2000,157:1660–1668.

    Article  PubMed  CAS  Google Scholar 

  11. Granholm E, Perry W, Filoteo JV, Braff D:Hemispheric and attentional contributions to perceptual organization deficits on the global-local task in schizophrenia.Neuropsychology 1999,13:271–281.

    Article  PubMed  CAS  Google Scholar 

  12. Granholm E, Cadenhead K, Shafer KM, Filoteo JV:Lateralized perceptual organization deficits on the global-local task in schizotypal personality disorder.J Abnorm Psychol 2002,111:42–52.

    Article  PubMed  Google Scholar 

  13. Hardoy MC, Carta MG, Catena M,et al.:Impairment in visual and spatial perception in schizophrenia and delusional disorder.Psychiatry Res 2004,127:163–166.

    Article  PubMed  Google Scholar 

  14. Trestman RL, Keefe RS, Mitropoulou V,et al.:Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder.Psychiatry Res 1995,59:127–136.

    Article  PubMed  CAS  Google Scholar 

  15. Lees Roitman SE, Cornblatt BA, Bergman A,et al.:Attentional functioning in schizotypal personality disorder.Am J Psychiatry 1997,154:655–660.

    Google Scholar 

  16. Franke P, Maier W, Hardt J,et al.:Attentional abilities and measures of schizotypy: their variation and covariation in schizophrenic patients, their siblings, and normal control subjects.Psychiatry Res 1994,54:259–272.

    Article  PubMed  CAS  Google Scholar 

  17. Harvey PD, Moriarty PJ, Serper MR,et al.:Practice-related improvement in information processing with novel antipsychotic treatment.Schizophr Res 2000,46:139–148.

    Article  PubMed  CAS  Google Scholar 

  18. Moriarty PJ, Harvey PD, Mitropoulou V,et al.:Reduced processing resource availability in schizotypal personality disorder: evidence from a dual-task CPT study.J Clin Exp Neuropsychol 2003,25:335–347.

    Article  PubMed  Google Scholar 

  19. Barch DM, Mitropoulou V, Harvey PD,et al.:Context-processing deficits in schizotypal personality disorder.J Abnorm Psychol 2004,113:556–568.

    Article  PubMed  Google Scholar 

  20. Voglmaier MM, Seidman LJ, Salisbury D, McCarley RW:Neuropsychological dysfunction in schizotypal personality disorder: A profile analysis.Biol Psychiatry 1997,41:530–540.

    Article  PubMed  CAS  Google Scholar 

  21. Mitropoulou V, Harvey PD, Maldari LA,et al.:Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity.Biol Psychiatry 2002,52:1175–1182.

    Article  PubMed  Google Scholar 

  22. Brebion G, Amador X, Smith MJ, Gorman JM:Mechanisms underlying memory impairment in schizophrenia.Psychol Med 1997,27:383–393.

    Article  PubMed  CAS  Google Scholar 

  23. Bowie CR, Harvey PD, Moriarty PJ,et al.:A comprehensive analysis of verbal fluency deficit in geriatric schizophrenia.Arch Clin Neuropsychol 2004,19:289–303.

    Article  PubMed  CAS  Google Scholar 

  24. Keete RS, Roitman SE, Harvey PD,et al.:A pen and paper human analogue of a monkey prefrontal cortex activation task: Spatial working memory in patients with schizophrenia.Schizophr Res 1995,17:25–33.

    Article  Google Scholar 

  25. Mitropoulou V, Harvey PD, Zegarelli G,et al.:Neuropsychological performance in schizotypal personality disorder: importance of working memory.Am J Psychiatry 2005,162:1896–1903.

    Article  PubMed  Google Scholar 

  26. Levitt JJ, McCarley RW, Dickey CC,et al.:MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder.Am J Psychiatry 2002,159:1190–1197.

    Article  PubMed  Google Scholar 

  27. Kraepelin E:Dementia Praecox and Paraphrenia. Edinburgh: E&S Livingstone; 1919.

    Google Scholar 

  28. Bleuler E:Dementia Praecox; or the Group of Schizophrenias. New York: International Universities Press; 1911.

    Google Scholar 

  29. Heaton RK, Pendleton MG:Use of neuropsychological tests to predict patients everyday functioning.J Consult Clin Psychology 1981,49:807–821.

    Article  CAS  Google Scholar 

  30. Green MF:What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry 1996,153:321–330.

    PubMed  CAS  Google Scholar 

  31. Green MF, Kern RS, Braff DL, Mintz J:Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the “right stuff”? Schizophr Bull 2000,26:119–136.

    PubMed  CAS  Google Scholar 

  32. Bowie CR, Reichenberg A, Rieckmann N,et al.:Stability and functional correlates of memory-based classification in older schizophrenia patients.Am J Geriatr Psychiatry 2004,12:376–386.

    Article  PubMed  Google Scholar 

  33. Skodol AE, Gunderson IG, McGlashan TH,et al.:Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder.Am J Psychiatry 2002,159:276–283.

    Article  PubMed  Google Scholar 

  34. Dickey CC, McCarley RW, Niznikiewicz MA,et al.:Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder.Schizophr Res 2005,78:297–308.

    Article  PubMed  Google Scholar 

  35. Harvey PD, Keefe RS:Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment.Am J Psychiatry 2001,158:176–184.

    Article  PubMed  CAS  Google Scholar 

  36. Harvey PD, Bowie CR, Loebel A:Neuropsychological normalization with long-term atypical antipsychotic treatment: results of a 6-month randomized double-comparison of ziprasidone vs. olanzapine.J Neuropsychiatry Clin Neurosciences, In press.

  37. Koenigsberg HW, Reynolds D, Goodman M,et al.:Risperidone in the treatment of schizotypal personality disorder.J Clin Psychiatry 2003,64:628–634.

    Article  PubMed  CAS  Google Scholar 

  38. Siegel Jr BV, Trestman RL, O’Flaithbheartaigh S,et al.:D-amphetamine challenge effects on Wisconsin Card Sort Test. Performance in schizotypal personality disorder.Schizophr Res 1996,20:29–32.

    Article  PubMed  Google Scholar 

  39. Kirrane RM, Mitropoulou V, Nunn M,et al.:Effects of amphetamine on visuospatial working memory performance in schizophrenia spectrum personality disorder.Neuropsychopharmacology 2000,22:14–18.

    Article  PubMed  CAS  Google Scholar 

  40. Kirrane RM, Mitropoulou V, Nunn M,et al.:Physostigmine and cognition in schizotypal personality disorder.Schizophr Res 2001,48:1–5.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Psychiatry, Mount Sinai School of Medicine, 1425 Madison Avenue, 4th Floor, Box 1230, 10029, New York, NY, USA

    Christopher R. Bowie PhD

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  1. Christopher R. Bowie PhD
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Bowie, C.R. Cognitive impairment in schizophrenia spectrum personality. Current Psychosis & Therapeutics Reports 3, 147–151 (2005). https://doi.org/10.1007/BF02629446

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