Abstract
The effect of two nootropics, piracetam and N-phenylacetyl-L-prolyglycine ethyl ester (GVS-111), is studied by measuring high-threshold K+ and Ca2+ currents in isolated snail neurons using a two-microelectrode patch-clamp technique. Piracetam and GVS-111 are shown to reduce the amplitude of both the K+ and the Ca2+ (to a lesser extent) current. The threshold concentrations for GVS-111 and piracetam are 10−9-10−8 M and 1–5×10−4 M, respectively. It is assumed that the antiamnestic effect of the nootropics is partially mediated by a blockade of ion channels of the neuronal membrane.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 2, pp. 151–155, February, 1996
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Solntseva, E.I., Bukanova, Y.V., Ostrovskaya, R.U. et al. Effects of the nootropics piracetam and GVS-111 on voltage-dependent ion channels of neuronal membranes. Bull Exp Biol Med 121, 138–142 (1996). https://doi.org/10.1007/BF02446618
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DOI: https://doi.org/10.1007/BF02446618