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Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice

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Abstract

The type II collagen induced arthritis model was used to evaluate the efficacy of tissue inhibitor of metalloproteases (TIMP) in suppressing the disease in DBA/1 mice. Treatment began following the first clinical manifestations of the disease state. Clinical observations, histological and radiographic findings show a decreased incidence of joint erosion in the treated population relative to the controls. It is concluded that systemic administration of recombinant human TIMP suppresses the pathology of type II collagen induced arthritis.

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Authors and Affiliations

  1. Synergen Inc., 1885 33rd St., 80301, Boulder, CO

    D. F. Carmichael

  2. Division of Dermatology, Veterans Administration Medical Center and Department of Dermatology, Vanderbilt University, School of Medicine, 27232, Nashville, TN

    G. P. Stricklin

  3. Veterans Administration Medical Center, 1030 Jefferson Ave., 38104, Memphis, TN, USA

    J. M. Stuart

Authors
  1. D. F. Carmichael
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  2. G. P. Stricklin
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  3. J. M. Stuart
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Carmichael, D.F., Stricklin, G.P. & Stuart, J.M. Systemic administration of TIMP in the treatment of collagen-induced arthritis in mice. Agents and Actions 27, 378–379 (1989). https://doi.org/10.1007/BF01972827

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  • DOI: https://doi.org/10.1007/BF01972827

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