Skip to main content
SpringerLink
Log in

Adjuvant polyarthritis. VIII. Differences in immunopathogenesis between type II collagen arthritis and adjuvant arthritis

  • Immunosuppression and Inflammation
  • Editorial
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The severity of type II collagen-induced arthritis was found to correlate with the serum tiers of anti-type II collagen antibody, but not with cell-mediated immunity to type II collagen. In contrast, no significant levels of either the humoral or the cell-mediated immunity to type II collagen were found in ras with Freund's complete adjuvant-induced arthritis. Pre-treatment of young rats with an oily preparation of type II collagen prevented the development of arthritis in these animals in response to a subsequent injection of oily preparation of type II collagen, but had no effect on the development of arthritis in response to a subsequent injection of Freund's complete adjuvant. It is concluded that while an immune response directed toward the injected type II collagen is responsible for the development of type II collagen arthritis, it does not play an important role in the induction of Freund's adjuvant-induced arthritis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. C.M. Pearson,Experimental joint disease. Observations on adjuvant-induced arthritis, J. chron. Dis.16, 16–863 (1963).

    Article  Google Scholar 

  2. F. Quagliata andJ.M. Phillips-Quagliata,Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity evidence that mycobacterial components are required for the successful transfer of the disease, Cell. Immunol.3, 78 (1972).

    Article  PubMed  Google Scholar 

  3. F. Wood, C.M. Pearson andA. Tanaka,Capacity of mycobacterial wax D and its, subfractions to induce adjuvant arthritis in rats, Int. Archs Allergy appl. Immun.35, 456 (1969).

    Google Scholar 

  4. C.M. Pearson andF. Wood,Passive transfer of adjuvant arthritis by lymph node or spleen cells, J. exp. Med.120, 547 (1964).

    Google Scholar 

  5. H. Berry, D.A. Willoughby andJ.P. Giroud,Evidence for an endogenous antigen in the adjuvant arthritic rat, J. Path.III, 229 (1973).

    Article  Google Scholar 

  6. Y.-H. Chang, C.M. Pearson andC. Abe,Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: Immunologic, histopathologic and other studies, Arthritis Rheum.23, (1980).

  7. D.E. Trentham, W.J. McCune, P. Susman and J.R. David, J.R.Autoimmunity to collagen in adjuvant arthritis of rats, J. clin. Invest.66, 1109 (1980).

    PubMed  Google Scholar 

  8. Y.-H. Chang, C.M. Pearson andL. Chedid,Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-l-alanyl-d-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan, J. exp. Med. 153, 1021 (1981).

    Article  PubMed  Google Scholar 

  9. D.E. Trentham, A.S. Townes andA.H. Kang,Autoimmunity to type II collagen: an experimental model of arthritis, J. exp. Med.146, 857 (1977).

    Article  PubMed  Google Scholar 

  10. D.E. Trentham, A.S. Townes, A.H. Kang andJ.R. David,Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats, J. clin. Invest.61, 89 (1978).

    PubMed  Google Scholar 

  11. M.A. Cremer, J.M. Stuart, A.S. Townes andA.H. Kang,A study of native type II collagen for adjuvant activity, J. Immun.124, 2912 (1980).

    PubMed  Google Scholar 

  12. Y. Iizuka and Y.-H. Chang,Adjuvant polyarthritis. VII. The role of type II collagen in pathogenesis, Arthritis Rheum.25, 181 (1982).

    PubMed  Google Scholar 

  13. J.M. Stuart, A.M. Cremer, S.N. Dixit, A.H. Kang andA.S. Townes,Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens, Arthritis Rheum.22 347 (1979).

    PubMed  Google Scholar 

  14. D.H. Winter, E.A. Risley and G.W. Nuss,Carrageenin-induced edema in hindpaw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. exp. Biol. Med.111, 544 (1962).

    Google Scholar 

  15. J.M. Stuart, A.M. Cremer, A.H. Kang andA.S. Townes,Collagen-induced arthritis in rats. Evaluation of early immunologic events, Arthritis Rheum.22, 1344 (1979).

    PubMed  Google Scholar 

  16. C.M. Pearson,Development of arthritis, periarthritis, and periostitis in rats given adjuvants, Proc. Soc. exp. Biol. Med.91, 95 (1956).

    PubMed  Google Scholar 

  17. M.M. Griffiths, E.J. Eichwald, J.H. Martin, C.B. Smith andC.W. DeWitt,Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats, Arthritis Rheum.24, 781 (1981).

    PubMed  Google Scholar 

  18. C.M. Pearson, B.H. Waksman andJ.T. Sharp,Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes: Comparison of the experimental process with human disease, J. exp. Med.113, 485 (1961).

    Article  PubMed  Google Scholar 

  19. T.S. Koga, S. Sakamoto, K. Onoue, S. Kotani andA. Sumiyoshi,Efficient induction of collagen arthritis by the use of a synthetic muramyl dipeptide, Arthritis Rheum.23, 993 (1980).

    PubMed  Google Scholar 

  20. J.S. Courtney, M.J. Dallman, A.D. Dayan, A. Martin andB. Mosedale,Immunization against heterologous type II collagen induces arthritis in mice, Nature, Lond.283, 666 (1980).

    Google Scholar 

  21. B.H. Waksman andC. Wennersten,Passive transfer of adjuvant arthritis in rats with living lyphoid cells of sensitized donors, Int. Archs Allergy appl. Immun.23, 129 (1963).

    Google Scholar 

  22. D.J. Whitehouse M.W. Whitehouse andC.M. Pearson,Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes, Nature Lond.224, 1322 (1969).

    PubMed  Google Scholar 

  23. J.M. Stuart, M.A. Cremer, A.S. Townes andA.H. Kang,Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibody can cause arthritis, J. exp. Med.155, 1 (1982).

    Article  PubMed  Google Scholar 

  24. S.S. Kerwar, M.E. Englert, P.A. McReynolds, M.J. Landes, J.M. Lloyd, A.L. Oronsky andF.J. Wilson,Type II collagen-induced arthritis: Studies with purified anti-collagen immunoglobulin, Arthritis Rheum.26, 1120 (1983).

    PubMed  Google Scholar 

  25. Y.-H. Chang, Unpublished observation.

Download references

Author information

Author notes

  1. Yoshio Iizuka (Associate Research Rheumatologist)

    Present address: Central Res. Lab. No. 2-58, Sankyo Co. Ltd., Hiromachi 1-Chome, Shinagawa-ku, 140, Tokyo, Japan

Authors and Affiliations

  1. Department of Medicine, UCLA School of Medicine, 90024, Los Angeles, California

    Yi-Han Chang & Yoshio Iizuka (Associate Research Rheumatologist)

Authors
  1. Yi-Han Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshio Iizuka
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by US Public Health Service, National Institutes of Health Grant AM 26571.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, YH., Iizuka, Y. Adjuvant polyarthritis. VIII. Differences in immunopathogenesis between type II collagen arthritis and adjuvant arthritis. Agents and Actions 15, 529–534 (1984). https://doi.org/10.1007/BF01966768

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01966768

Search

Navigation